Premature coronary heart disease has emerged as a major cause of morbidity and mortality in systemic autoimmune diseases. Recent epidemiologic and pathogenesis studies have suggested a great deal in common between the pathogenesis of prototypic autoimmune disease such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) and that of atherosclerosis. Some of the most remarkable dat...

Introduction: Behçet’s disease (BD) is an autoimmune, multisystemic vasculitis characterized by chronic inflammation. Autoimmune responses in BD could drive inflammation which a risk for malignant transformation. Some genetic, environmental, clinical features and immunosuppressive treatments may increase the of malignancy. Common genetic factors similar environmental play role pathogenesis some...

multiple sclerosis (ms) is an autoimmune disease, which is characterized by demyelination and neuroinflammation. extracellular matrix (ecm) have important role in the central nervous system (cns). alterations are happening to the ecm after the cns disorder like ms, alzheimer and other neural injury. tenasin-c (tnc) is a glycoprotein that is highly expressed in inflammatory conditions of the cns...

objective: autoimmune diseases precede a complex dysregulation of the immune system. t helper17 (th17) and interleukin (il)-17 have central roles in initiation of inflammation and subsequent autoimmune diseases. il-27 significantly controls autoimmune diseases by th17 and il-17 suppression. in the present study we have created genetic engineered mesenchymal stem cells (mscs) that mediate with l...

Introduction: Autoimmune hepatitis is an inflammatory liver disorder histologically characterized by portal lymphoplasmocytic with interface activity and lobular inflammation.
 Aims: To identify clinical characteristics associated older age also to pinpoint significant inflammation in histology.
 Methods: Cross-sectional analytical study that evaluated medical records of adult patient...

Background: Autoimmune hepatitis (AIH) in childhood has variable modes of presentation, and the disease should be suspected and excluded in all children presenting with symptoms and signs of prolonged or severe acute liver disease. In AIH, the liver biopsy histopathology shows inflammation in addition to presence of serum autoimmune antibodies and increased levels of immunoglobulin G (IgG). Ob...

Objective: Triptolide, the active component of Tripterygium wilfordii Hook F has been used to treat autoimmune and inflammatory conditions for over two hundred years in traditional Chinese medicine. However, the processes through which triptolide exerts immunosuppression and anti-inflammation are not understood well. In this review, we discuss the autoimmune disorders and inflammatory condition...

Atrophic gastritis, whether caused by Helicobacter pylori infection or as a result of an autoimmune process, is associated with corpus atrophy. However, whereas atrophic gastritis caused by H. pylori involves the antrum, the antrum is spared in autoimmune gastritis. Here, we report the use of magnifying endoscopy to identify and distinguish atrophic gastritis caused by H. pylori from autoimmune...