autoimmune polyglandular syndrome (aps) type 2 is characterized by the presence of addison's disease, in association with autoimmune thyroid disease and/or type 1 diabetes mellitus. aps type 2 occurs most often in middle aged females and is rare in children. here an 11 year old boy is reported with addison's disease who developed symptom's of diabetes mellitus, goiter, malabsorption, macrocytic...

Autoimmune hepatitis (AIH) is a progressive, chronic liver disease characterized by unresolving hepatocellular inflammation of autoimmune origin. The clinical spectrum may vary from asymptomatic presentation, to non-specific symptoms such as fatigue, arthralgias, nausea and abdominal pain, to acute severe liver disease. AIH is characterized by the presence of interface hepatitis and portal plas...

Citation for published version (APA): Liberal, R., Grant, C. R., Holder, B. S., Cardone, J., Martinez-llordella, M., Ma, Y., ... Longhi, M. S. (2015). In autoimmune hepatitis type 1 or the autoimmune hepatitis-sclerosing cholangitis variant defective regulatory Tcell responsiveness to IL-2 results in low IL-10 production and impaired suppression. Hepatology, 62(3), 863875. DOI: 10.1002/hep.27884

10.2217/14750708.2.3.447 © 2 part of Chronic hepatitis C virus infection is associated with an increased risk for the development of Type 2 diabetes mellitus. Proposed mechanisms include increased insulin resistance, development of nonalcoholic fatty liver disease and direct infection of the pancreas by hepatitis C virus. However, the development of Type 1 diabetes mellitus is usually associate...

The prevalence of serum antibodies to hepatitis C virus (HCV) was assessed by an enzyme-linked immunosorbent assay in 46 patients seropositive for liver-kidney microsomal antibody (anti-LKM1), the marker of autoimmune hepatitis type 2. 43 had chronic hepatitis (with histological confirmation in 34) and 3 were seropositive for anti-LKM1 without clinical or biochemical evidence of liver damage. T...