refractory celiac disease (rcd) is when malabsorption symptoms and villous atrophy persist despite strict adherence to a gluten free diet (gfd) for more than 12 months and other causes of villous atrophy have been ruled out.  rcd is considered a rare disease and almost exclusively occurs in adults. persistent diarrhea, abdominal pain, weight loss are the most common symptoms in rcd. also, anemi...

Four patients with collagen diseases are described, who developed protein losing enteropathy in the course of their disease. Their protein losing enteropathies subsided after treatment with 60 mg/day oral prednisolone. Immunohistological studies of the small intestine showed deposits of C3 in the capillary walls of villi in two patients. Increased capillary permeability due to autoimmune phenom...

Monogenic primary immunodeficiency syndromes can affect one or more endocrine organs by autoimmunity during childhood. Clinical manifestations include type 1 diabetes mellitus, hypothyroidism, adrenal insufficiency, and vitiligo. Lipopolysaccharide (LPS)-responsive beige-like anchor protein (LRBA) deficiency was described in 2012 as a novel primary immunodeficiency, predominantly causing immune...

The value of proximal intestinal mucosal biopsy was reviewed in 381 children presenting with chronic diarrhoea over an eight year period. An enteropathy was detected in 44% of cases and was more frequently seen in those aged less than 6 months. A diagnosis was established in 91% of cases. The most common diagnosis was the postenteritis syndrome where the presence of an enteropathy indicated tho...

BACKGROUND Although sarcoidosis and celiac disease are both chronic immunologic disorders involving multiple organ systems, reports about association of diseases in individual patients are sparse. While sarcoidosis is a chronic granulomatous disease presumably reflecting an exaggerated response to an unknown antigen, celiac disease is a T cell-driven disease triggered by ingestion of gluten, a ...

Tufting enteropathy First described in 1994, tufting enteropathy is a clinicopathological entity in which infants present with watery diarrhea in the first month of life. The pattern of inheritance appears to be autosomal recessive. Jejunal biopsy shows partial or subtotal villous atrophy with normal or hyperplastic crypts. The lamina propria is not inflamed and intraepithelial lymphocytes are ...

Currently, gluten enteropathy (celiac disease) is one of the most urgent diseases with a genetically determined, autoimmune profile, which significantly reduces social adaptation and quality life patients. In recent years, there has been increased interest in studying relationship between celiac disease female reproductive dysfunction, but available data are contradictory. It necessary to furth...