The Gulf Journal of Dermatology and Venereology ABSTRACT Psoriasis vulgaris and bullous pemphigoid represent two clinically well-characterized, chronic, inflammatory skin diseases. The concomitant occurrence of these two entities in a patient is rare, and the exact nature of this relationship is not clear. We describe a 31-year-old woman with a history of plaque-type psoriasis who presented wit...

Background & Objective: Autoimmune bullous diseases are associated with autoimmunity against structural components in the skin and mucous membranes. Autoantibodies are against the intercellular junctions in pemphigus disease and hemidesmosomal unchoring complex in pemphigiod diseases and epidermolysis bullosa aquisita. The tissue-bound and circulating serum autoantibodies can be detected with d...

Autoimmune blistering diseases (pemphigus vulgaris, pemphigus foliaceus, bullous pemphigoid, dermatitis herpetiformis) and certain genodermatoses with acantholysis (Darier-disease, Hailey-Hailey disease) have different aetiological factors, but all result in bulla formation and/or in acantholysis. Cadherins are Ca++-dependent cell-cell adhesion molecules which play an important role in the cell...

Coagulation activation has been demonstrated in two prototypic autoimmune skin diseases, chronic autoimmune urticaria and bullous pemphigoid, but only the latter is associated with increased thrombotic risk. Two markers of coagulation activation (prothrombin fragment F1+2 and fibrin fragment D-dimer) were measured by immunoenzymatic methods in plasma samples from 30 patients with active chronic...

In this observation, we describe a combination of three autoimmune diseases in the same patient namely vitiligo evolving since childhood, autoimmune dermo epidermal bullous dermatosis and autoimmune thrombocytopenia. The discovery of such associations may limit the therapeutic arsenal. And temporal sequence indicates that long-term surveillance of these patients is necessary to watch the occurr...

Orf is a rare viral zoonosis due to Parapoxvirus infection. Transmission humans occurs through contact with infected goats and sheep. It may be complicated by fever, lymphangitis, lymphadenopathy, bacterial infection, erythema multiforme. Only several cases of autoimmune bullous dermatoses have been described. Bullous pemphigoid secondary an orf was found in ten patients. Herein, we report one ...

Background: Bullous diseases are classified as autoimmune blistering diseases, hereditary disorders, and secondary to inflammation physical trauma. This study evaluated clinicopathological features of patients with bullous diseases. Methods: is a retrospective cross-sectional 88 vesiculobullous referred the dermatology clinic Afzalipour hospital in Kerman, Iran. Demographic patients, type lesio...

Therapeutics of autoimmune bullous disease has seen a major shift of focus from more global immunosuppression to targeted immunotherapy. Anti CD 20 monoclonal antibody Rituximab revolutionized the therapeutics of autoimmune bullous disease particularly pemphigus. Though it is still being practiced off-label, evidences in the form of RCT and meta analysis are now available. Other novel anti CD 2...

Systemic lupus erythematosus (SLE) is an episodic, potentially fatal, multisystem autoimmune disease characterized by the presence of antinuclear antibodies especially to double stranded DNA. Bullous systemic lupus erythematosus is an extremely rare subset of lupus erythematosus. We report a 10-year-old boy with bullous SLE and nephrotic syndrome.

Autoimmune bullous diseases result from an immune response to molecular components of the desmosome or basement membrane. Bullous diseases are associated with a high degree of morbidity and occasional mortality. Therapy of bullous diseases consists of suppressing the immune system, controlling inflammation and improving healing of erosions. The therapeutic agents used in the treatment of bullou...