Background and Purpose—Previous P–magnetic resonance spectroscopy (P-MRS) studies have shown that cerebral cortical energy metabolism is abnormal in migraine and that cortical energy reserves decrease with increasing severity and duration of aura. Migrainous infarction is a rare complication of migraine with aura, and its pathophysiology is poorly understood. We used P-MRS to determine whether ...

This study examined the efficacy of lamotrigine in the prevention of migraine aura. Fifty nine patients suffering from migraine with aura received lamotrigine in a controlled three year prospective open study. Treatment response was defined as a reduction of aura frequency each month by at least 50%. Primary endpoint was reached by three quarters of the patients. Lamotrigine significantly reduc...

AURA (Advanced Uncertain Reasoning Architecture) is a generic family of techniques and implementations intended for high-speed approximate search and match operations on large unstructured datasets. AURA technology is based upon binary Correlation Matrix Memories (CMM). This paper describes a high performance IP-core for executing the core AURA operations. The IP-core processes the AURA data in...

BACKGROUND Headache can be associated with epilepsy as a pre-ictal, ictal, or post-ictal phenomenon; however, studies of patients with headache as an epileptic aura are scarce. We performed the present study to investigate the incidence and characteristics of headache as an epileptic aura, via confirmation of electroencephalography (EEG) changes by video-EEG monitoring. METHODS Data of aura a...

CLINICAL HISTORY A 28-year-old woman has migraine with visual aura about two times per month. The visual aura lasts about 30 minutes and is followed by a hemicranial throbbing headache, which becomes severe associated with nausea, light, and noise sensitivity with a duration of up to 24 hours. Questions.—Would an oral triptan or sumatriptan administered subcutaneously be more effective if given...

Migraine with aura (MA) is characterized by cortical dysfunction. Frequent aura attacks may alter cerebral cortical structure in patients, or structural grey matter abnormalities may predispose MA patients to aura attacks. In the present study we aimed to investigate cerebral grey matter structure in a large group of MA patients with and without sensory aura (i.e. gradually developing, transien...

Previous studies suggest an abnormal cerebral cortical energy metabolism in migraineurs. If causally related to the pathophysiology of migraine, these abnormalities might show a dose-response relationship with the duration and severity of aura symptoms. While such a trend has been suggested in phosphorus spectroscopy (31P-MRS) studies, it has not been considered in proton spectroscopy (1H-MRS) ...

Typical migraine aura is a short-lived sensory experience coming before or during migraine and experienced by about 1/4 of all migraineurs. The experience can be visual, sensory, or result in problems with speaking or word finding. Typical visual changes are seeing spots, zigzags or crescents, flashes of light, or losing sight partially or fully, with any one of these lasting between 5 minutes ...