Human papillomavirus (HPV)infection consists the majority of cervical precancerous lesions and cancers. Various screening programmes aim in indentifying HPV infection preventing cancer. We present a 20-year-old female patient whose first pap smear revealed atypical squamous cells undetermined significance (ASCUS). Pap smear, followed by genotyping evaluation, high-risk 33 infiltration. Colposco...

A group of 146 experts representing 29 organizations and professional societies met September 18-19, 2006, in Bethesda, MD, to develop revised evidence-based, consensus guidelines for managing women with abnormal cervical cancer screening tests. Recommendations for managing atypical squamous cells of undetermined significance and low-grade squamous intraepithelial lesion (LSIL) are essentially ...

PURPOSE GRIM-19 has been shown to be down-regulated in cervical cancers. This study investigated the expression of GRIM-19 in cervical intra-epithelial neoplasias and its association with high-risk human papillomavirus (HR-HPV) infection. METHODS The expression of GRIM-19 was assessed in cervical exfoliated cells and cervical intra-epithelial neoplasia tissues by immunohistochemistry, and the...

We report the prevalence and genotype distribution of human papillomaviruses (HPVs) among Japanese women with abnormal cervical cytology using the PGMY-CHUV assay, one of PGMY-PCR-based lineblot assays that was validated and shown to be suitable for the detection of multiple HPV types in a specimen with minimum bias. Total DNA was extracted from cervical exfoliated cells collected from 326 outp...

INTRODUCTION Retrospective evaluation of cervical smear results of women who attended our gynecology policlinics with various symptoms and discussion of the results in the light of the literature. MATERIAL AND METHODS We performed a retrospective investigation on 37,438 Pap smear results of women who attended our hospital between January 2011 and December 2012 with a variety of symptoms. RE...

Background and aims: Cervical cancer is the fourth most common cancer in women worldwide and the 13th in Jordan. The cervical smear (Pap smear) is a simple approach to detect pre-cancerous cervical lesions. The aim of this study was to evaluate the prevalence of abnormal cervical smears in women seen at the Early Detection/Community Outreach clinic of King Hussein Cancer Center (KHCC). Material...

High-grade squamous intraepithelial lesion (HSIL) smear is one of the categories of squamous cell abnormality in the 2001 Bethesda System. HSIL denotes cases who have abnormal squamous cells with an increased nuclear/ cytoplasmic ratio, marked atypical nucleus, and irregular nuclear border (Wright et al., 2011). At the present, HSIL is acknowledged as a high-grade cervical smear abnormality. Ac...

The MonoPrep Pap Test (MPPT; MonoGen, Lincolnshire, IL) is a novel, liquid-based specimen collection and processing technology for cytologic and molecular testing. Its usefulness in the detection of cervical cancer and its precursors was evaluated in a multicenter, masked, adjudicated, split-sample study of 10,739 samples. After preparation of a conventional smear, the residuum on the collectio...

Aim. Cervical cancer is one of the most common female malignancy with high mortality rates in developing countries. Our purpose is to present cervical cytologic abnormalities and the detection rate of epithelial abnormalities by cervical cytology (CC). Method. A total of 8972 conventional pap smear tests collected between August 2010 and August 2012 from Çankırı State Hospital were retrospectiv...

BACKGROUND We recently reported, using a receiver operating characteristic area metric, the first meta-analytic comparison of the relative accuracy of cervical and anal cytology in detecting moderate or severe histopathologic lesions by magnification directed punch biopsy. The aim of the present research was to meta-analytically examine cut-point specific operating characteristics (sensitivity,...