A 37 year old male with a history of peptic ulcer disease presented to the emergency room with nausea and vomiting. He reported two recent episodes of syncope, but denied other associated symptoms including palpitations, hematemesis, melena, chest pain, or dyspnea. He reported recent use of marijuana, but denied use of cocaine or methamphetamines. The patient reported similar symptoms in 2006 w...

Because somatostatin, a neuroregulatory peptide, is found in abundance in the atria and atrioventricular node, its electrophysiological and antiarrhythmic properties were compared with those of verapamil in ten patients with paroxysmal atrioventricular tachycardia. During sinus rhythm, intravenous somatostatin slowed the heart rate whereas verapamil increased it. Though both agents prolonged at...

RATIONALE The clinically important atrioventricular conduction axis is structurally complex and heterogeneous, and its molecular composition and developmental origin are uncertain. OBJECTIVE To assess the molecular composition and 3D architecture of the atrioventricular conduction axis in the postnatal mouse heart and to define the developmental origin of its component parts. METHODS AND RE...

Previous studies have suggested that maintained vagal stimulation or acetylcholine infusion results in a fade of responses in the sinoatrial node but not in the atrioventricular node, implying different muscarinic receptor subtypes in the two regions. We investigated this hypothesis in 23 isolated rabbit atrial preparations made quiescent by continuous superfusion with verapamil (1 microgram/ml...

anotomical boundary of atrioventricular node reentrant tachycardia (avnrt) is composed of fast and slow pathways right atrium in upper turnaround and common distal pathway in lower turnaround. we performed electophsiologic study (eps) in 152 patients and could show the existence of distal common pathway with decremental conduction properties in approximately 40 patients.

His bundle electrograms were recorded in 2 adult cases of congenital corrected transposition of the great arteries. Both patients had prolonged HV conduction and a His potential that was wide. These findings are different from those reported in congenital atrioventricular block without ventricular inversion wherein an abnormality within the AHperiod has been found. It is suggested that these di...