introduction: human embryonic stem cells (hescs) are pluripotent cells that can proliferate and differentiate to many cell types. their electrophysiological properties have not yet been chracterzed. in this study, the passive properties (such as resting membrane potential, input resistance and capacitance) and the contribution of delayed rectifier k+ channel currents to the membrane conductance...

Introduction: Human embryonic stem cells (hESCs) are pluripotent cells that can proliferate and differentiate to many cell types. Their electrophysiological properties have not yet been chracterzed. In this study, the passive properties (such as resting membrane potential, input resistance and capacitance) and the contribution of delayed rectifier K+ channel currents to the membrane conducta...

there are many reports for involvement of atp-sensitive potassium channels in pancreatic, cardiac and vascular smooth muscle cells. this study examined the effect of single doses of k+ channel openers diazoxide, minoxidil and k+ channel blockers chlorpropamide, glibenclamide on serum concentration of aldosterone in male rats. blood samples were obtained 60 minutes after drug treatment and serum...

Introduction: Intracellular pH (pHi) regulates essentially all aspects of cellular activities. However, it is unknown how endoplasmic reticulum (ER) potassium channels sense pHi. In this study, we investigate the direct effects of pHi on ER potassium channels. Methods: We used channel incorporation into the bilayer lipid membrane method. L-α-phosphatidylcholine, a membrane lipid, was extrac...