This article aimed to investigate changes in the cytoskeleton of airway smooth muscle cells (ASMCs) in juvenile rats with airway remodeling in asthma. We further investigated the involvement of the RhoA/ROCK signaling pathway mechanism. Rat models of airway remodeling in asthma were established by antigen sensitization with ovalbumin for 2, 4, 6, and 8 weeks. The control group was treated with ...

This study aimed to investigate the possible molecular mechanisms of active ingredients of Epimedii Folium (EF) and Ligustri Lucidi Fructus (LLF) combined with Budesonide (Bun) in asthmatic rats. Rats were divided into 5 groups, including normal group, asthma model group, Bun group, group of active ingredients of EL and LLF (EL), and group of coadministration of Bun with EL (Bun&EL). The asthma...

A new rat asthma model was devised, and with the model, allergic bronchoconstrictor responses and effects of disodium cromoglycate (DSCG) were compared among Wistar, Lewis and Fischer 344 rats. Rats were actively sensitized with DNP-Ascaris antigen (DNP-As) and killed Bordetella pertussis vaccine. After eight days, asthmatic response was provoked by inhalation of DNP-As. The bronchomotor respon...

BACKGROUND The inhalation of allergens by allergic asthmatics results in the early asthmatic response (EAR), which is characterized by acute airway obstruction beginning within a few minutes. The EAR is the earliest indicator of the pathological progression of allergic asthma. Because the molecular mechanism underlying the EAR is not fully defined, this study will contribute to a better underst...

This researchaims to stud the role of Glutathione-S-transferases in asthma under stress conditions. Also, evaluate the ability of Iraqi propolis to inhibit the free radicals production in asthmatic rats too.GST enzyme was partially purified from rats liver after induction asthma. The experimental Sprague-Dawly rats were divided into four groups. (G1) control group, (G2) asthma group, (G3) asthm...

The objectives of the study were to detect the effect of substance P receptor antagonist aprepitant on a rat model of asthma and depression. Ovalbumin (OVA)-induced asthmatic Wistar rats were exposed to a chronic mild stress (CMS) procedure which was usually used to induce depression in animals. Simultaneously with the CMS, two groups of the rats were respectively given either aprepitant or sla...

Introduction: Asthma is a chronic inflammatory disorder of the airways often characterized by airway remodeling and influx cells into airways. Saffron (C. sativus) has been reported to possess anti-inflammatory, anti-allergic immunomodulatory properties. Salbutamol known relax smooth muscles. Objective: To investigate combined anti-asthmatic effect C. sativus extract (CSE) salbutamol in an oval...