نتایج جستجو برای: associated protein bap

تعداد نتایج: 2524810  

Journal: :Clinical journal of the American Society of Nephrology : CJASN 2011
Christiane Drechsler Marion Verduijn Stefan Pilz Raymond T Krediet Friedo W Dekker Christoph Wanner Markus Ketteler Elisabeth W Boeschoten Vincent Brandenburg

BACKGROUND AND OBJECTIVES Serum alkaline phosphatase (AP) is associated with vascular calcification and mortality in hemodialysis patients, but AP derives from various tissues of origin. The aim of this study was to assess the effect of bone-specific AP (BAP) on morbidity and mortality in dialysis patients. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS From a prospective cohort study of incid...

Journal: :Applied and environmental microbiology 2010
Yoshiaki Maeda Tomoko Yoshino Tadashi Matsunaga

Escherichia coli biotin ligase can attach biotin molecules to a lysine residue of biotin acceptor peptide (BAP), and biotinylation of particular BAP-fused proteins in cells was carried out by coexpression of E. coli biotin ligase (in vivo biotinylation). This in vivo biotinylation technology has been applied for protein purification, analysis of protein localization, and protein-protein interac...

Journal: :Toxicological sciences : an official journal of the Society of Toxicology 2008
Ayako Nakayama Ivan Riesen Bernd Köllner Elisabeth Eppler Helmut Segner

Polycyclic aromatic hydrocarbons (PAHs) such as benzo[a]pyrene (BaP) are immunotoxic to fish. Metabolism of PAHs in immune cells has been implicated in PAH immunotoxicity in mammals, but for fish the presence of metabolic enzymes in immune cells is less clear. The objective of this study was to examine localization and induction of the BaP-metabolizing biotransformation enzyme, cytochrome P4501...

Journal: :Plant physiology 2013
Markéta Žd'árská Pavlína Zatloukalová Mariana Benítez Ondrej Šedo David Potěšil Ondřej Novák Jana Svačinová Bedrich Pešek Jiří Malbeck Jana Vašíčková Zbyněk Zdráhal Jan Hejátko

The plant hormones cytokinins (CKs) regulate multiple developmental and physiological processes in Arabidopsis (Arabidopsis thaliana). Responses to CKs vary in different organs and tissues (e.g. the response to CKs has been shown to be opposite in shoot and root samples). However, the tissue-specific targets of CKs and the mechanisms underlying such specificity remain largely unclear. Here, we ...

2016
Sudhir K. Shukla

Staphylococcus aureus is one of the most common root causes of nosocomial infections because of its dominant biofilm forming property. Staphylococci infection is common in both humans and animals. Biofilms have been implicated in almost 60% of all bacterial infections [1]. The bacterial biofilm formation is governed by several factors that are under the control of diverse genetic elements [2]. ...

2015
Anke Doyon Dagmar-Christiane Fischer Aysun Karabay Bayazit Nur Canpolat Ali Duzova Betül Sözeri Justine Bacchetta Ayse Balat Anja Büscher Cengiz Candan Nilgun Cakar Osman Donmez Jiri Dusek Martina Heckel Günter Klaus Sevgi Mir Gül Özcelik Lale Sever Rukshana Shroff Enrico Vidal Elke Wühl Matthias Gondan Anette Melk Uwe Querfeld Dieter Haffner Franz Schaefer

OBJECTIVES The extent and relevance of altered bone metabolism for statural growth in children with chronic kidney disease is controversial. We analyzed the impact of renal dysfunction and recombinant growth hormone therapy on a panel of serum markers of bone metabolism in a large pediatric chronic kidney disease cohort. METHODS Bone alkaline phosphatase (BAP), tartrate-resistant acid phospha...

Journal: :Carcinogenesis 2005
Xia Wen U Kristina Walle Thomas Walle

The objective of this study was to examine the ability of dietary polyphenols to inhibit cytochrome P450 (CYP) 1A1 expression and activity and benzo[a]pyrene (BaP) DNA binding, with the main emphasis on prevention of chemical-induced hepatic carcinogenesis. For this purpose we used Hep G2 cells, a good model of the normal human hepatocyte for CYP1A1 cell signaling. First, when these cells were ...

Journal: :Orphanet Journal of Rare Diseases 2021

Abstract Background Degos disease is a rare vascular disorder with cutaneous-limited form, benign atrophic papulosis (BAP), and systemic variant, malignant (MAP). Despite the poor prognosis of MAP, no study has established features associated disease. Objectives The aims this systematic review were to: (1) summarize clinical treatments implemented for patients MAP BAP (2) identify laboratory fa...

Journal: :Environmental toxicology and pharmacology 2013
Petr Hodek Jitka Koblihová René Kizek Eva Frei Volker M Arlt Marie Stiborová

Benzo[a]pyrene (BaP) is a human carcinogen requiring metabolic activation prior to reaction with DNA. Cytochrome P450 (CYP) 1A1 is the most important hepatic and intestinal enzyme in both BaP activation and detoxification. CYP1A2 is also capable of oxidizing BaP, but to a lesser extent. The induction of CYP1A1/2 by BaP and/or β-naphthoflavone in liver and small intestine of rats was investigate...

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