Deep brain stimulation (DBS) is the surgical procedure of choice for patients with advanced Parkinson disease (PD). We aim to evaluate the efficacy of GPi (globus pallidus internus), STN (subthalamic nucleus)-DBS and medical therapy for PD. We conducted a systematic review and multiple-treatments meta-analysis to investigate the efficacy of neurostimulation and medical therapy for PD patients. ...

Background: In Parkinson’s disease, deep brain stimulation (DBS) of the subthalamic nucleus (STN) or globus pallidus internus (GPi) produces comparable motor benefits. Although both increases risk cognition and verbal fluency (VF) decline, is greater following STN-DBS. The consequences stimulating these different sites on network activity unknown. We use functional magnetic resonance imaging (f...

Background and objective: Anterior thalamic nucleus deep brain stimulation (ATN-DBS) has been shown to be an effective method in seizure reduction. However, its underlying mechanisms remain unclear. This study aimed to determine the potential beneficial effects of ATN-DBS on hippocampus in epileptic rhesus monkeys. Methods: Eighteen rhesus monkeys were randomly divided into three groups: contro...

the technology of neural stimulation in recent years has become the focus of the research and treatment, although it has been around for many years. the potential use of stimulating the brain and nerves ranges from the spinal cord stimulation to the implantations of cochlear and bionic eyes with a large discrepancy between the clinical readiness for these various uses. electrical high-frequency...

obsessive-compulsive disorder (ocd) is a psychiatric disorder manifested by thoughts and impulses that produce anxiety and result in patients performing repetitive rituals. treatment generally consists of cognitive behavioral intervention and serotonin reuptake inhibitors. up to 40% of patients will have functional impairment that significantly affects their quality of life. in the late 1990’s,...

Deep brain stimulation (DBS) is a treatment modality that has been shown to improve the clinical outcomes of individuals with movement disorders, including Parkinson's disease. Directional DBS represents an advance in field allows clinicians better modulate electrical increase therapeutic gains while minimizing side effects. In this review, we summarize principles directional DBS, available tec...