ABSTRACT Knoevenagel condensation of barbituric acids with aromatic aldehydes containing one or two formyl groups was carried out. 5-Arylidenebarbituric acids underwent smooth hetero-Diels-Alder (HDA) reactions with enol ethers to afford cis and trans diastereoisomers of pyrano[2,3-d]pyrimidine-2,4-diones and 5,5'-(1,4-phenylene)bis[2H-pyrano[2,3-d]pyrimidine-2,4(3H)-dione] derivatives in excel...

BACKGROUND There are only limited publications devoted to the synthesis of especially thiazolo[3,2-a]quinazoline which involved reaction of 2-mercaptopropargyl quinazolin-4-one with various aryl iodides catalyzed by Pd-Cu or by condensation of 2-mercapto-4-oxoquinazoline with chloroacetic acid, inspite of this procedure was also reported in the literature to afford the thiazolo [2,3-b] quinazol...

An earlier study (1) from this laboratory proved conclusively that Amytal, 5-ethyl-5-isoamylbarbituric acid (I), is not detoxified by simple hydrolysis of the barbituric acid ring and indicated that the alkyl side chain (or chains) must suffer alteration in viva. Recently (2), it was discovered that the isomeric drug, pentobarbital, is excreted as the diastereoisomers of 5-ethyl-5-(3-hydroxy-1-...

Convenient procedure for the synthesis of corresponding pyrano[2,3-d]pyrimidine derivatives were developed via one-pot three-component reaction of aryl aldehyde derivatives, malononitrile with barbituric acids in the presence of copper (II) chloride dihydrate (CuCl2.2H2O) as highly efficient Lewis acid catalyst. This protocol has advantages such as readily and inexpensive catalyst, high reactio...

garlic, an antioxidant plant, can react with amino groups of proteins to form schiff bases. as diabetes leads to glycation of various proteins and this in turn has some effects on the structure of proteins and biochemical activity of them, the inhibition of this process seems very vital. for several years researchers in this field have done their best to recognize the antidiabetic compounds. th...

Spin crossover complexes based on either iron(II) or iron(III) give a colorimetric response upon self-assembly with barbituric acids. They can be used as visible sensors for these narcotics, selectively detecting barbiturates in the presence of other biologically-relevant hydrogen bonding species.

Lipid peroxidation was measured by the thio-barbituric assay for malondialdehyde (MDA). A small amount of MDA was formed when medial cells from guinea pig aorta were grown in tissue culture. The polyunsaturated fatty acids 8,11,14-eicosatrienoic acid, 5,8,11,14-eicosatetraenoic acid, and 7,10,13,16-docosatetraenoic acid generated significant amounts of MDA in a time-dependent manner when they w...

Earlier studies (1, 2) from this laboratory indicated that in the dog the alkyl side chains of pentobarbital and Amytal do not undergo w oxidation but are subject to oxidation at the y-carbon atom of the amyl chains. Dogs excrete pentobarbital as two optically active diastereoisomers of ethyl(3hydroxy-1-methylbutyl)barbituric acid and Amytal as ethyl(3-hydroxyisoamyl)barbituric acid. In order t...

Since the 1864 landmark discovery by Adolf von Baeyer, barbituric acids have played a prominent role in medicine and organic synthesis. The barbituric acid scaffold occurs in more than 5000 pharmacologically active compounds, including commonly used anticonvulsant, hypnotic, and anticancer agents (Figure 1a). Moreover, as an easily accessible feedstock material, it is an extremely useful buildi...

A simple, efficient and environment-friendly procedure for the synthesis of 5-arylidene rhodanines derivatives via a Knoevenagel type reaction was developed using rhodanine, variety differently substituted aldehydes Na2SO3 as benign catalyst in ethanol. Selected were subjected to basic hydrolysis afford 2-mercapto-3-substituted-acrylic acids. The presence boronic acid group is well tolerated su...