a simple and environmentally benign procedure for the synthesis of 14-aryl-14h-dibenzo[a,j]xanthenes by a one-pot condensation of 2-naphthol with aromatic aldehyde in the presence of [et3nh][hso4] as an acidic ionic liquid catalyst under solvent-free conditions has been developed. the reaction work-up is very simple and the catalyst can be easily separated from the reaction mixture and reused s...

Aldehyde phenyl hydrazones 2a-i undergo oxidative dehydrogenation with Chloramine-T to give nitrile imines, which are trapped in situ by ethyl oleate 1 to afford 8-(5-Aryl-4-octyl-2-phenyl-3,4-dihydro-2Hpyrazol-3-yl)-octanoic acid ethyl esters 3a-i in good yield. The structures of the cycloadducts were confirmed by spectral studies and elemental analysis.

The intramolecular alpha-arylation of aldehydes has been accomplished using singly occupied molecular orbital (SOMO) catalysis. Selective oxidation of chiral enamines (formed by the condensation of an aldehyde and a secondary amine catalyst) leads to the formation of a 3pi-electron radical species. These chiral SOMO-activated radical cations undergo enantioselective reaction with an array of pe...

1,2,3-Triaminoguanidinium chloride was combined with benzaldehyde and hydratropic aldehyde to furnish the corresponding tris(imines), which were converted into 1,2,3-tris(benzylamino)guanidinium salts by catalytic hydrogenation in the former, and by borane reduction in the latter case. The resulting alkyl-substituted triaminoguanidinium salts underwent a threefold carbamoylation with aryl isocy...

A highly efficient enantioselective aryl addition to aldehydes using boroxins as aryl source and conformationally restricted perhydro-1,3-benzoxazines as ligands is reported. Both enantiomeric forms of chiral arylphenylmethanols and 1,1'-disubstituted diarylmethanols are afforded with excellent yields and enantioselectivities using the same ligand by means of an appropriate combination of borox...

Titanium chelate addition of aryl nucleophiles to cyclopropyl aldehyde 6 followed by a tin-catalyzed one-pot retro-aldol, acetalisation and lactonisation sequence afforded cis and trans γ-aryllactone acetals. A γ-furyllactone derived by this approach was further transformed in two steps to model compounds for the oxidised northeastern sectors of selected Pseudopterogorgia diterpenoids.

The total synthesis of the human telomerase inhibitor γ-rubromycin in its racemic form was accomplished in 3.8 % overall yield. The key feature of this synthesis is an efficient acid-catalyzed spiroketalization for the construction of the spiroketal core. The required electronically well-balanced spiroketal precursor was obtained by the convergent assembly of a naphthyl-substituted aldehyde, an...

We hereby report a mild and efficient coupling reaction between alkyl aldehydes and aryl diamines. In the presence of a Cu(2+) or a Zn(2+) ion, oxygen (O2) in air is able to promote the oxidative condensation of the two readily preparable functional groups, forming stable benzimidazole linkages in neutral aqueous solution at room temperature (RT). We demonstrated that the reaction could be util...

A simple and efficient synthesis of aryl and heteroaryl substituted pyrimidines has been developed via initial Knoevenagal, subsequent addition and final cyclization of aldehyde, ethylcyanoacetate and guanidine nitrate. Piperidine has been used as a catalyst. Short reaction time, environment friendly procedure and excellent yields are the advantages of this procedure. All synthesized compounds ...

Abstract The cobalt‐catalyzed reaction between 1,3‐dithiolanes and Grignard reagents, for the efficient synthesis of multi‐substituted alkene products, is described. method was applicable to a variety benzylic dithiolane substrates, affording di‐, tri‐, tetra‐substituted 1,1‐diaryl products in good excellent yields. use reagents with aryl aldehyde‐derived enabled access natural product‐derived ...