*Correspondence: 9 Department of Biochemistry and Biomedical Sciences, Health Sciences Centre, Room 10 4H24, McMaster University, 1200 Main Street West, Hamilton, Ontario, L8N3Z5, 11 Canada. Phone: 1-905-525-9140 Ext 22703 Fax: 1-905-522-9033. 12 e-mail: [email protected] 13 14 Running Title: DegP: A Structure Driven Functional Model 15

BACKGROUND Clinical trials that end prematurely (or "terminate") raise financial, ethical, and scientific concerns. The extent to which the results of such trials are disseminated and the reasons for termination have not been well characterized. METHODS AND FINDINGS A cross-sectional, descriptive study of terminated clinical trials posted on the ClinicalTrials.gov results database as of Febru...

Any opinions expressed in this memoir are those of the author(s) and do not necessarily reflect the views of the National Academy of Sciences. r o B e r t h o f s t a d t e r Biographical Memoir Copyright 1994 national aCademy of sCienCes washington d.C.

This article reviews the development of catalysts for ring-opening metathesis polymerization (ROMP), synthesis of polymers bearing amino acids and peptides by ROMP of functionalized norbornenes, formation of aggregates and micelles, and applications of the polymers to medical materials. It also describes the control of monomer unit sequences, that is, living polymerization to synthesize block c...

The online version of the original article can be found under doi:10.1007/s10951-009-0135-7. A.R. Clark ( ) Bristol Institute of Technology, University of the West of England, Frenchay Campus, Bristol BS16 1QY, UK e-mail: [email protected] R. Morabito Production Engineering Department, Universidade Federal de São Carlos, Campus de São Carlos, Rodovia Washington Luís (SP-310), Km 235, São...

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A PCR assay with primers derived from the 16S rRNA sequence of Brucella abortus was developed. Nine different combinations between six primers were tested. One pair of primers, which amplified a 905-bp fragment, was selected. As little as 80 fg of Brucella DNA was detected by this method. DNAs from all of the representative strains of the species and biovars of Brucella and from 23 different Br...