Travelling is an activity closely associated with Carolus Linnaeus (1707-1778) and his circle of students. This article discusses the transformative role of studying nature outdoors (turning novices into naturalists) in eighteenth-century Sweden, using the little-known journeys of Carl Bäck (1760-1776), Sven Anders Hedin (1750-1821) and Johan Lindwall (1743-1796) as examples. On these journeys,...

Background: Unloading of skeletal muscle causes atrophy and loss of contractile function. In part, this response is believed to be mediated by the transcription factor nuclear factor-kappa B (NFκB). Both curcumin, a component of the spice turmeric, and N-acetylcysteine (NAC), an antioxidant, inhibit activation of NF-κB by inflammatory stimuli, albeit by different mechanisms. In the present stud...

Distinct changes of the spectral and variability properties observed in black hole transients during a bright outburst deliver insight into evolution accretion flow geometry. We investigated NICER Swift monitoring observations H 1743–322 its 2018 as well NuSTAR XMM-Newton data. The hardness ratios, rms amplitudes, quasiperiodic oscillations indicate that showed another hard-state-only, or so-ca...

Chlorogenic acid derivatives were recently identified as novel, potent, and specific inhibitors of the hepatic glucose 6-phosphate translocase. Inhibition of the glucose 6-phosphate translocase leads to a decrease in hepatic glucose production, rendering chlorogenic acid derivatives as potential novel therapeutics in patients with type 2 diabetes. The present study examines the hepatic uptake m...