UNLABELLED POPE (Phylogeny, Ortholog and Paralog Extractor) provides an integrated platform for automatic ortholog identification. Intermediate steps can be visualized, modified and analyzed in order to assess and improve the underlying quality of orthology and paralogy assignments. AVAILABILITY POPE is available for download from the website: http://www.well.ox.ac.uk/~tota/pope.

Domain formation in bacteria-mimetic membranes due to cationic peptide binding was recently proposed based on calorimetric data. We now use (2)H solid-state NMR to critically examine the presence and absence of domains in bacterial membranes containing zwitterionic 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphatidylethanolamine (POPE) and anionic 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphatidylglycero...

Phospholipid-coatings on metallic implant surfaces were evaluated in terms of adhesion, proliferation and matrix production of skeletal cells, and of macrophage stimulation. The working hypothesis is that mimicking a model biomembrane by phospholipids on surfaces to which cells adhere, the surface recognition by surrounding cells is altered. In this study, 1) mirror-like polished Ti-6Al-7Nb and...

We investigated interactions of the lipid raft molecules sphingomyelin (SM) and cholesterol (CHOL) in monolayers and bilayers composed of 1-palmitoyl-2-oleoyl-sn-glycerophosphatidylethanolamine (POPE) or 1-palmitoyl-2-docosahexaenoyl-sn-glycerophosphatidylethanolamine (PDPE) at 35 degrees C. Techniques employed were pressure-area (pi-A) isotherms generated from Langmuir-Blodgett films, solid-st...

In utero exposure to ethanol continues to be a significant public health issue and neonatal healthcare professionals are in need of objective means to identify exposed newborns. The aim of this study was to fully validate two methods for the detection of two direct alcohol biomarkers, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanol (POPE) and ethyl glucuronide (EtG), in umbilical cord and appl...

Alexander Pope (1688±1744): his spinal deformity and his doctors. O.P. Sharma. #ERS Journals Ltd 1999. ABSTRACT: Alexander Pope was the towering figure of 18th century England. A poet and a wit he commanded unswerving loyalty from his friends and penetrating hatred from his enemies. His spinal deformity, either due to tuberculosis, trauma or congenital weakness, shaped his career. This brief re...

A Coluna Prestes, tem a ver com dois personagens que se tornaram lenda, no cenário cultural nordestino: Padre Cícero Romão Batista (1844-1934) e Virgulino Ferreira da Silva (1898-1938), É o este artigo propõe entender, partir de como deu inusitado surpreendente cruzamento, tão distintas histórias personalidades. foi um evento histórico ocorrido entre os anos 1925 1927, do século XX. Ficou conhe...