BACKGROUND The modification of speech properties in patients may indicate a more profound pathology. Ample research has been undertaken in relation to different demographic and genetic factors on arthritis but significant research on speech in arthritis had not been conducted globally. The objective of this study was to investigate the effect of arthritis on the duration of speech in patients. ...

OBJECTIVE To demonstrate that posttranslational modification of type II collagen (CII) by reactive oxygen species (ROS), which are known to be present in inflamed arthritic joints, can give rise to epitopes specific to damaged cartilage in rheumatoid arthritis (RA) and osteoarthritis (OA) and to establish a proof of concept that antibodies specific to ROS-modified CII can be used to target ther...

1 Physiology Division, Zoology Department, Faculty of Science, BeniSuef University, Beni-Suef, Egypt 2 Cell Biology, Genetic Engineering and Biotechnology Research Center, Sadat University, Sadat City, Egypt 3 Pathology Department, Faculty of Veterinary Medicine, BeniSuef University, Beni-Suef, Egypt * Corresponding Author’s E-mail: [email protected]; [email protected] This study...

Luffa Echinata Roxb. fruits popularly known, as ‘Bindal’ in Hindi is a slender herb belonging to the Cucurbitaceae which grows widely in India. In traditional system of medicine, Luffa echinata Roxb. fruits were used for various ailments including inflammation, diabetes etc. To investigate the folkloric use of the fruits the present study was carried out on Freund’s adjuvant induced arthritic r...

Intradermal inoculation of rats at the tail base with Mycobacterium butyricum led to the gradual development of an arthritic swelling of the limbs which peaked at 3 weeks and subsided thereafter. Arthritic rats displayed a loss of body weight, hypophagia, and hypodipsia in addition to a disruption of the diurnal rhythms of ingestive behavior and of core temperature. The activity of adenohypophy...

Rheumatoid arthritis is a common severe joint disease that affects all age groups, it is thus of great importance to develop new strategies for its treatment. The aim of the present study was to examine the combined effect of coenzyme Q₁₀ (CoQ₁₀) and methotrexate (MTX) on the progression of adjuvant-induced arthritis in rats. Adjuvant arthritis (AA) was induced by a single intradermal injection...

Methotrexate (MTX) is still the gold standard for treatment of rheumatoid arthritis (RA). The therapeutic efficacy of low-dose of MTX can be increased by its combination with a natural substance, ferulaldehyde (FRA). The aim of this study was to evaluate the effect FRA and MTX administered alone or in combination in adjuvant arthritis. The disease was induced to Lewis male rats by intradermal i...

BACKGROUND The roots and stem bark of Berberis orthobotrys (Berberidaceae) have long been used traditionally to treat joint pain. Though, it has not been pharmacologically assessed for rheumatoid arthritis. The current study explores anti-arthritic activity and phytochemical analysis of aqueous-methanolic extract (30:70) and fractions (ethyl acetate, n-butanol, and aqueous) of Berberis orthobot...

BACKGROUND The synaptic and cellular mechanisms of pain-related central sensitization in the spinal cord are not fully understood yet. Calcitonin gene-related peptide (CGRP) has been identified as an important molecule in spinal nociceptive processing and ensuing behavioral responses, but its contribution to synaptic plasticity, cellular mechanisms and site of action in the spinal cord remain t...

Chronic arthritis induces hypermetabolism and cachexia. Ghrelin is a gastrointestinal hormone that has been proposed as a treatment to prevent cachexia. The aim of this work was to examine the effect of administration of the ghrelin agonist growth hormone-releasing peptide-2 (GHRP-2) to arthritic rats. Male Wistar rats were injected with Freund's adjuvant, and 15 days later arthritic and contro...