نتایج جستجو برای: arrhythmogenicity
تعداد نتایج: 246 فیلتر نتایج به سال:
Early after depolarizations (EAD) occur in many pathological conditions, such as congenital or acquired channelopathies, drug induced arrhythmias, and several other situations that are associated with increased arrhythmogenicity. In this paper we present an overview of the relevant computational studies on spatial EAD dynamics in 1D, 2D, and in 3D anatomical models and discuss the relation of E...
Introduction Focal atrial tachycardia (AT) mechanisms include enhanced automaticity and triggered activity. Autonomically mediated focal atrial arrhythmias (AT or atrial fibrillation [AF]) are rare. Adrenergic stimulation such as exercise or stress can initiate focal atrial arrhythmias by enhancing automaticity, whereas vagal nerve arrhythmogenicity is associated with reentry and early afterdep...
The relationship between alternans and arrhythmogenicity was studied in genetically modified murine hearts modeling catecholaminergic polymorphic ventricular tachycardia (CPVT) during Langendorff perfusion, before and after treatment with catecholamines and a β-adrenergic antagonist. Heterozygous (RyR2(p/s)) and homozygous (RyR2(s/s)) RyR2-P2328S hearts, and wild-type (WT) controls, were studie...
INTRODUCTION Brugada syndrome (BrS) is associated with loss of Na(+) channel function and increased risks of a ventricular tachycardia exacerbated by flecainide but reduced by quinidine. Previous studies in nongenetic models have implicated both altered conduction times and repolarization gradients in this arrhythmogenicity. We compared activation latencies and spatial differences in action pot...
BACKGROUND Detailed profiles of acute hypothermia and electrocardiographic (ECG) manifestations of arrhythmogenicity were examined to analyze acute hypothermia and ventricular arrhythmogenic potential immediately after portal vein unclamping (PVU) in living-donor liver transplantation (LT). METHODS We retrospectively analyzed electronically archived medical records (n = 148) of beat-to-beat E...
OBJECTIVE Ventricular tachyarrhythmias (VTs) occur frequently in patients having long QT syndrome (LQTS) or after acute myocardial ischemia. However, the synergistic effects of ischemia and LQTS on arrhythmia development are unclear. We evaluated the contribution of a prior episode of ischemia on the arrhythmogenicity of the LQTS. METHODS Using a 256-channel optical mapping system, we mapped ...
OBJECTIVES The purpose of this study was to evaluate the antiarrhythmic potential of mesenchymal stem cells (MSC) under a different environment. BACKGROUND Little is known about how environmental status affects antiarrhythmic potential of MSCs. METHODS To investigate the effect of paracrine factors secreted from MSCs under different circumstances on arrhythmogenicity in rats with myocardial...
Watanabe, Tetsu, Michiyasu Yamaki, Isao Kubota, Hidetada Tachibana, and Hitonobu Tomoike. Relation between activation sequence fluctuation and arrhythmogenicity in sodium-channel blockades. Am. J. Physiol. 277 (Heart Circ. Physiol. 46): H971–H977, 1999.—To examine the correlation between activation sequence fluctuation and arrhythmogenicity, we investigated temporal changes in the activation se...
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