The quality is typically modeled as the univariate or multivariate distribution of quality characteristic/s. In recent applications of statistical process control, quality profiles in which the relationship between a response and explanatory variable/s is captured and monitored are increasingly used to model the quality. Several techniques have been developed to enhance the speed of detecting c...

Tight control of synapse formation ensures that neurons connect to appropriate targets. In this issue of Neuron, Klassen et al. identify ARL-8 GTPase as a regulator of presynaptic assembly. Without ARL-8, presynaptic material aggregates en route to its destination, suggesting that ARL-8 acts like a dispersant to prevent premature synaptic assembly in the axon.

The objective of this paper is to present explicit analytical formulas for evaluating important characteristics of Double Moving Average control chart (DMA) for Poisson distribution. The most popular characteristics of a control chart are Average Run Length ( 0 ARL ) the mean of observations that are taken before a system is signaled to be out-of control when it is actually still incontrol, and...

Late endocytic organelles including lysosomes are highly dynamic acidic organelles. Late endosomes and lysosomes directly fuse for content mixing to form hybrid organelles, from which lysosomes are reformed. It is not fully understood how these processes are regulated and maintained. Here we show that the Caenorhabditis elegans ARL-8 GTPase is localized primarily to lysosomes and involved in la...

Active reinforcement learning (ARL) is a variant on reinforcement learning where the agent does not observe the reward unless it chooses to pay a query cost c > 0. The central question of ARL is how to quantify the long-term value of reward information. Even in multi-armed bandits, computing the value of this information is intractable and we have to rely on heuristics. We propose and evaluate ...

Usually, there are two phases in constructing a multivariate control chart. Phase I is to estimate the in-control process parameters and to establish control limits using historical data. Phase II is when the control limits are used to monitor the process. This paper focuses on determining the optimal number of samples in Phase I since number of samples affect the cost of quality control in pra...

This paper introduces a new, faster sorting algorithm (ARL – Adaptive Left Radix) that does in-place, non-stable sorting. Left Radix, often called MSD (Most Significant Digit) radix, is not new in itself, but the adaptive feature and the in-place sorting ability are new features. ARL does sorting with only internal moves in the array, and uses a dynamically defined radix for each pass. ALR is a...

A study of the perceived prestige of a core group of library journals by directors of ARL libraries and library school deans reveals a prestige hierarchy for each group. Although in rough agreement on the rating of two-thirds of the journals, the deans and directors differ significantly on the ratings of the remaining one-third. The subset of ARL directors in institutions where librarians have ...

S UMOylation of the small GTPase ARL-13 helps target signaling receptors into primary cilia, Li et al. reveal. Primary cilia are microtubule-based membrane protru-sions that serve as hubs for multiple signaling pathways. In C. elegans, ARL-13 promotes cilia assembly by coordinating intrafl agellar transport along ciliary microtubules, and the GTPase is also required for the correct localization...

Acrolein is a highly reactive alpha,beta-unsaturated aldehyde produced endogenously during lipid peroxidation and naturally distributed pervasively in living environments, posing serious threats to human health if not properly metabolized. In this study, we report aldose reductase-like-1 (ARL-1) as a novel enzyme that catalyzes the reduction of acrolein and protects cells from their toxicity. U...