INTRODUCTION In assessing erythropoietic agents for chemotherapy-induced anemia, traditional single time-point end points (e.g., hematopoietic response [HR]) fail to reflect clinical benefits over the entire therapy course. Area under the hemoglobin change curve (Hb AUC) is introduced as an alternative measure, and its reliability, clinical significance, and superiority are assessed. METHODS ...

background: the relationships between adiponectin and clinical outcomes in hemodialysis (hd) patients remain highly controversial. meanwhile, the association between adiponectin and the peripheral artery disease (pad) has not been well studied in hd patients without diabetic mellitus. materials and methods: the ankle-brachial index was measured in hd patients. adiponectin levels in 105 hd patie...

Abstract. The area under the curve (AUC) measures such as the area under the receiver operating characteristics curve (AUROC) and the area under the precision-recall curve (AUPR) are known to be more appropriate than the error rate, especially, for imbalanced data sets. There are several algorithms to optimize AUC measures instead of minimizing the error rate. However, this idea has not been fu...

The area under the ROC curve (AUC) is a widely used performance measure in machine learning. Increasingly, however, in several applications, ranging from ranking and biometric screening to medical diagnosis, performance is measured not in terms of the full area under the ROC curve, but instead, in terms of the partial area under the ROC curve between two specified false positive rates. In this ...

the pharmacokinetics of cefpirome was investigated in buffalo calves following its single intramuscular (im) administration (10 mg). the peak plasma concentration of cefpirome at 30 min was 9.0 ± 0.5 μg.ml-1, which declined to 0.2 ± 0.1 μg.ml -1 at 24 hrs. the absorption half-life (t1/2ka) and elimination half-life (t1/2 β) were 0.19 ± 0.03 hr and 2.39 ± 0.05 hr, respectively. the area under th...