bstract—Pigment epithelium-derived factor (PEDF) protects mmature cerebellar granule cell neurons (CGCs) against apotosis induced by K and serum deprivation. However, the recise mechanism of this protection remains unknown. We ecently reported that the transcription factor nuclear factor appa B (NFB) is activated in PEDF-treated CGCs. Although it s well known that NFB blocks apoptotic cell deat...

Bonamiosis due to the parasite Bonamia ostreae has been associated with massive mortality outbreaks in European flat oyster stocks in Europe. As eradication and treatment are not possible, the control of the disease mainly relies on transfer restriction. Moreover, selection has been applied to produce resistant flat oyster families, which present better survival and lower prevalence than non-se...

During partial nephrectomy, the avoidance of ischemic renal damage is extremely important as duration of renal artery clamping (i.e., ischemia) influences postoperative kidney function. Mitochondria (main producer of ATP in the cell) are very sensitive to ischemia and undergo damage during oxidative stress. Finding of a compound which diminishes ischemic injury to kidney is of great importance....

Triggering receptor expressed on myeloid cells-1(TREM-1) is a member of the superimmunoglobulin receptor family. We have previously shown that TREM-1 prolongs survival of macrophages treated with lipoolysaccharide through Egr2-Bcl2 signaling. Recent studies suggest a role for TREM-1 in viral immunity. Human immunodeficiency virus-1 (HIV) targets the monocyte/macrophage lineage at varying stages...

Treatment of ovarian cancer remains an important problem in practical oncology due to the increase morbidity and mortality from this disease. The aim is summarize available literature data on molecular mechanisms participation various proteins autophagy apoptosis development, progression, formation chemoresistance assessment prognosis epithelial cancer. Materials methods. search for information...

It is widely reported that reactive oxygen species (ROS) cause apotosis and carcinogenesis. Marked infiltration of activated leukocyte and enhanced production of ROS appear to occur in the gastric mucosa infected with Helicobacter pylori (H. pylori). The previous studies reported that the mutation of the succinate dehydrogenase subunit C (SDHC) gene caused the increase in superoxide anion (O(2)...

Graphene, a two dimensional (2D) planar and hexagonal array of carbon atoms, interacts with biological systems in different ways. Pristine graphene has been found to produce different responses as compared to its nano-composites. Graphene and its derivatives have been tested for their toxic effects on human erythrocytes, skin fibroblasts and different human cell lines including HepG2, A498, Cac...