objective: the aim of this study was to evaluate the effect of sucrose on follicular survival rate and the incidence of apoptosis in rat ovarian tissue following vitrification. methods: ovaries of approximately 5-week-old female wistar rats were divided randomly into three groups: control (non-vitrified), vi (ethylene glycol + dimethyl sulfoxide) and vii (eg + dmso + 0.25 mol/lit sucrose). vit...

In recent years data on cancer incidence in the USA, the Netherlands, and in Hong Kong indicate a flattening and perhaps a turnover at advanced age, but no model has been successful in fitting this data and thus providing clues to the underlying biology. In this work we assume these data are reliable and free from bias. We find that a Beta distribution fits SEER age-specific cancer incidence da...

Cisplatin efficacy is dependent on dose. The cisplatin-induced apoptosis pathway can go through the ER stress which will activate Bax and Bak (proapoptosis) causing calcium homeostasis disorders to occur. Glutamine protective effect caspase-12 expression prevention of apoptotic events in renal proximal tubular epithelial cells unknown. This further study analyzes effects intravenous glutamine c...

In vitro culture of human ovarian tissue the following cryopreservation is proposed for follicular development. There are no techniques that guarantee successful maturation of the follicles within the excised tissue. The viability of cultured human ovarian tissue improved by adding some growth factors to the culture media. The efficiency of vitrification as the cryopreservation method for human...

We have examined the effects of inactivation of the p53 tumor suppressor gene on the incidence of apoptotic cell death in two stages of the adenoma-to-carcinoma progression in the intestine: in early adenomas where p53 mutations are rare and in highly dysplastic adenomas where loss of p53 occurs frequently. Homozygosity for an inactivating germ-line mutation of p53 had no effect on the incidenc...

OBJECTIVE To investigate sperm viability, incidence of apoptosis, and intracellular basal and induced reactive oxygen species (ROS) in sperm fractions. DESIGN Prospective controlled study. SETTING Center for Reproductive Medicine at a tertiary care hospital. METHOD(S) Liquefied seminal ejaculates (n = 12) prepared by density gradient centrifugation were reconstituted to 2 mL with phosphat...

Background: It seems that Vinca. herbacea has an anti-tumor effect. Here, the immunotherapeutic effect of this compound is assessed against human ovarian cancer (SKOV3) cells because of the high incidence of this tumor in women. Materials and Methods: The cytotoxic activity of V. herbacea extract against human ovarian cancer (SKOV3) cells was determined by MTT assay. The apoptosis-inducing pote...

background : skin cancer is the most common malignancy in the world. thus, the aim of this study was to determine the incidence trend of skin cancer in isfahan province, iran. methods: the present cross-sectional study was conducted using data registered during 2004-2008 in the disease management center and cancer registry system of the ministry of health and medical education. the trend of ski...