In contrast to the well defined mechanism of merocrine exocytosis, the mechanism of apocrine secretion, which was first described over 180 years ago, remains relatively uncharacterized. We identified apocrine secretory activity in the late prepupal salivary glands of Drosophila melanogaster just prior to the execution of programmed cell death (PCD). The excellent genetic tools available in Dros...

Accumulating evidence suggests that the risk of axillary osmidrosis is governed by a non-synonymous single nucleotide polymorphism (SNP) 538G>A in human ATP-binding cassette C11 (ABCC11) gene. However, little data are available for the expression of ABCC11 protein in human axillary apocrine glands that produce apocrine sweat-a source of odor from the armpits. To determine the effect of the non-...

a case of pleomorphic adenoma in sweat gland is reported here. the histopathologic report confirmed the diagnosis. pleomorphic adenoma is most common in salivary glands but very rare in sweat glands. pleomorphic adenoma in sweat gland and the similar tumors of eccring sweat gland are described that bear a striking resemblance to pleomorphic adenomas of salivary gland. upon closer examination, t...

A rare case of an apocrine tumor in the male perineal region is reported. A dermal cystic lesion developed in the region between the anus and scrotum of a 74-year-old Japanese male. The cystic lesion, measuring 3.5 x 5.0 cm in size, was lined by columnar or flattened epithelium with occasional apocrine features and supported by a basal myoepithelium lining. A mural nodule, measuring 1 x 1.5 cm ...

Neoplastic lesions of the skin are among the most common human malignancies. They originate from different skin tissues and structures such as:  epidermis  skin appendages (hair follicles, sebaceous glands, eccrine sweat glands, apocrine sweat glands)  pigment cells (melanocytes)  mesenchymal structures (fibrous tissue, fatty tissue, blood and lymphatic vessels, muscles)  nerves and APUD c...

Hidradenitis suppurativa is a chronic, recurrent, debilitating disease that presents with inflamed lesions in the apocrine glands of the body. The most common locations are the axillary, inguinal and anogenital areas. Hidradenitis suppurativa is caused primarily by follicular occlusion with secondary involvement of the apocrine glands. The authors report a case of 47-old-man with an 18-year his...

BACKGROUND Axillary osmidrosis is characterized by unpleasant odors originating from the axillary apocrine glands, resulting in psychosocial stress. The main treatment modality is apocrine gland removal. Until now, of the various surgical techniques have sometimes caused serious complications. We describe herein the favorable outcomes of a new method for ablating apocrine glands by minimal subd...

INTRODUCTION The classification of malignant sweat gland lesions is complex. Traditionally, cutaneous sweat gland tumors have been classified by either eccrine or apocrine features. METHODS A case report of a 33-year-old Hispanic man with a left scalp mass diagnosed as a malignancy of adnexal origin preoperatively is discussed. After presentation at our multidisciplinary tumor board, excision...