In the late 1990s, the internet boom required new techniques and practices from project management that were more overtly agile and (perceived as being) outside of the realm of traditional methodologies. At the time, and to this day to a large extent, traditional methodologies had been the single recognised toolset available to a project manager: and then only really addressing the ‘harder’ dis...

Introducción: la enfermedad hepática representa una de las principales causas morbimortalidad a nivel mundial, principalmente por cirrosis y hepatocarcinoma; sin embargo, se subestima su impacto para el paciente, sistema salud país. Materiales métodos: estudio descriptivo corte transversal que determinó carga económica asociada muertes prematuras tumores primarios del hígado, mediante valoració...

OBJECTIVE The inflammation that occurs during the development of atherosclerosis is characterized by a massive release of sPLA2-IIA (group IIA secretory phospholipase A2) from vascular smooth muscle cells (VSMCs). We have investigated the autocrine function of sPLA2-IIA in rat aortic and human VSMCs. METHODS AND RESULTS We found that the transcription of the endogenous sPLA2-IIA gene increase...