Proxazole or 3-α-phenylpropyl-5-β-diethylaminoethyl-1, 2 4-oxadiazole citrate, is an unusual drug because it possesses both anti-inflammatory and antispasmodic proper ties (1) and because each of these two properties has some uncommon features. The anti inflammatory action takes place mostly against edematous responses and is devoid of ul cerogenic effects which are instead produced ...

SJ-200 (Himcospaz), an herbal preparation, was investigated for antispasmodic activity on gastrointestinal smooth muscles of guinea pig, rats, rabbits, and mice. SJ-200 dosedependently inhibited acetylcholine, histamine and barium chloride-induced contraction of guinea pig ileum. It inhibited spontaneous contraction of rabbit and rat colon. Oxytocininduced contraction of rat uterus was also inh...

the aim of this study was to investigate the effect of aerial parts of stachys lavandulifolia vahl. extract on the rat ileum contractions. the crude extract was prepared by maceration method (90% methanol) followed by fractionating into chloroform, ethyl acetate, petroleum ether and water. in adult male wistar rats, ileum was sectioned and mounted in tissue bath and their contractility was reco...

background: citrus aurantium is a small citrus tree, with scented white flowers. the c. aurantium is used in asian herbal medicine primarily to treat digestive problems. objective: the goal of this study is to investigate the effect of c. aurantium flower's aqueous extract on uterine contraction in presence of some known uterus stimulants. materials and methods: in experimental study 30 virgin ...

Previous studies have described the antispasmodic effect of mangiferin, a natural glucoside xanthone (2-C-β-Dgluco-pyranosyl-1,3,6,7-tetrahydroxyxanthone) that is present in mango trees and other plants, but its mechanism of action remains unknown. The aim of this study was to examine the potential contribution of the nitric oxide-cyclic GMP pathway to the antispasmodic effect of mangiferin on ...

dracocephalum kotschyi boiss, a member of labiatae family, is a native plant to iran, which has been reported to have immunomodulatory, antihyperlipidemic and antispasmodic activities. the objective of this research was to study the antispasmodic and antidiarrhoeal activities of hydroalcoholic and hexane extracts of d. kotschyi in mice. furthermore, the antidiarrhoeal and antispasmodic effect o...

dracocephalum kotschyi boiss. (labiatae) is a traditional medicine which is believed to have antispasmodic and analgesic activities. the antispasmodic action of d. kotschyi essential oil has been shown in a previous report. the objective of this research was to study antispasmodic activity of hydroalcoholic extract of d. kotschyi on ileum contractions. hydroalcoholic extract was obtained from a...

In the past two decades, increasing consumption of synthetic drugs and its associated side effects has led World Health Organization (WHO) to study the antioxidant activity of this plant. It also conducted an ethno botanical survey of endemic medicinal plants studying its uses by the rural populations in order to prevent and treat many current diseases (1). Achillea species such as Achillea mil...