Background: Antipsychotics have been used for many years for the treatment of neurological disorders, and the application of antipsychotics in the elderly have increased in frequency over the past few years. The absolute benefit of typical as well as atypical antipsychotics have come into question as their safety in elderly population is not seem to be in sync with their theoretical assessments...

PURPOSE Previous research has suggested an association between use of atypical antipsychotics and onset of diabetes mellitus. We sought to compare the incidence of new onset diabetes among patients receiving atypical antipsychotics, traditional antipsychotics or antidepressants. METHODS Retrospective cohort study of outpatients with claims for atypical antipsychotics (n = 10 265) compared to ...

AIM To investigate the incidence of dyslipidemia (hypertriglyceridemia and hypercholesterolemia) in patients treated with antipsychotics of new generation compared to conventional therapy. METHODS This retrospective study included 116 chronic psychiatric patients divided into two groups: a test group who were on treatment with antipsychotics of the new generation and a control group who were ...

Antipsychotic medications are used to treat and manage symptoms for several psychiatric disorders and are commonly categorized into two classes. First-generation antipsychotics (FGAs), also known as “typical antipsychotics,” were developed in the 1950s. Secondgeneration antipsychotics (SGAs), also known as “atypical antipsychotics,” emerged in the 1980s. To date, FGAs have been classified accor...

The development of atypical (or second generation) antipsychotics has offered people with schizophrenia more treatment options. Atypical antipsychotics are judged to be more effective in alleviating symptoms of the illness and to be associated with fewer side-effects in most patients. They are more expensive than the earlier class of antipsychotics, so-called typical antipsychotics, but doubt r...

BACKGROUND A sudden change in antipsychotics in the pharmacotherapy of schizophrenia might worsen the clinical condition or induce a relapse of psychotic symptoms. This study reports on shifting from other antipsychotics to aripiprazole during the course of treatment, with further analysis of factors related to a successful switch. METHODS An observational study was conducted. Study subjects ...

Despite a large number of neuroimaging studies in schizophrenia reporting subtle brain abnormalities, we do not know to what extent such abnormalities reflect the effects of antipsychotic treatment on brain structure. We therefore systematically reviewed cross-sectional and follow-up structural brain imaging studies of patients with schizophrenia treated with antipsychotics. 30 magnetic resonan...

AIMS AND METHOD To establish if participants with schizophrenia receiving depot antipsychotics had less insight than similar participants receiving oral atypical antipsychotics.We assessed the difference between these two groups. RESULTS Participants on oral antipsychotics had greater insight than those on depot antipsychotics (ITAQ, P=0.01). In the multiple regression analysis, only receiving ...

AIMS AND METHOD To establish if participants with schizophrenia receiving depot antipsychotics had less insight than similar participants receiving oral atypical antipsychotics.We assessed the difference between these two groups. RESULTS Participants on oral antipsychotics had greater insight than those on depot antipsychotics (ITAQ, P=0.01). In the multiple regression analysis, only receiving ...