نتایج جستجو برای: antipruritic

تعداد نتایج: 204  

Introduction: For centuries, cannabinoids are known to be effective in pain relief. Itch is an unpleasant sensation that provokes a desire to scratch. Since itch and pain are two sensations sharing a lot in common, we aimed to investigate whether the cannabinoid agonist WIN 55,212-2 reduces serotonin-induced scratching behavior and also observe whether modulation of nitric oxide (NO) production...

Journal: :avicenna journal of phytomedicine 0
laura inocencio leite department of biology at the federal university of cariri, brejo santo – ce, brazil gerlânia de oliveira leite department of pharmacology, university of santa maria, santa maria- rs, brazil bruno anderson fernandes silva department of chemical biological at the regional university of cariri, crato – ce, brazil severino denício gonçalves sousa department of chemical biological at the regional university of cariri, crato – ce, brazil thales coutinho department of chemical biological at the regional university of cariri, crato – ce, brazil renata sampaio department of chemical biological at the regional university of cariri, crato – ce, brazil

objective: vanillosmopsis arborea baker (asteraceae) has high economic value from chapada to araripe and its bark essential oil is a potential source of alpha-bisabolol. the present study aimed to elucidate the antinociceptive and antipruritic properties of the essential oil of v. arborea baker (eova) in mice. materials and methods: the antinociceptive activity was assessed using the capsaicin,...

Journal: :Acta dermato-venereologica 2009
Sonja Ständer Barbara Böckenholt Funda Schürmeyer-Horst Carsten Weishaupt Gereon Heuft Thomas A Luger Gudrun Schneider

Chronic pruritus is difficult to treat and requires the evaluation of new therapeutic modalities. We initiated an open-labelled, two-arm prospective, proof-of-concept study applying two selective serotonin re-uptake inhibitors on a long-term basis. Paroxetine and fluvoxamine were tested in a total of 72 pruritic patients (27 men, 45 women, age range 28-88 years, mean age 59.2 years). The reduct...

Journal: :Acta dermato-venereologica 2017
Hjalte H Andersen Camilla Melholt Sigurd D Hilborg Anne Jerwiarz Amalie Randers Amalie Simoni Jesper Elberling Lars Arendt-Nielsen

A frequent empirical observation is that cold-induced counter-irritation may attenuate itch. The aim of this randomized, single-blinded, exploratory study was to evaluate the counter-irritation effects of cold-stimulation and topical application of transient receptor potential TRPA1/M8-agonists (trans-cinnamaldehyde/L-menthol, respectively), on histamine-induced itch, wheals and neurogenic infl...

2015
Amir Gal-Oz Shmuel Kivity Yacov Shacham Elisheva Fiszer Ori Rogowsky Gil Chernin

BACKGROUND Ethyl-chloride (EC) spray was recently shown to be an effective antipruritic agent, when given 15 min after histamine skin-prick test (SPT), without changing the wheal and flare reaction. We aimed to investigate the antipruritic effect of EC on SPT, when given prior to SPT. METHODS A double-blind placebo-controlled prospective study. Overall, 44 volunteers underwent histamine SPT o...

2017
Laura Inocencio Leite Gerlânia de Oliveira Leite Bruno Anderson Fernandes Silva Severino Denício Gonçalves Sousa Thales Silva Coutinho Renata Souza Sampaio Irwin Menezes José Galberto Martins Costa Adriana Rolim Campos

OBJECTIVE Vanillosmopsis arborea Baker (Asteraceae) has high economic value from Chapada to Araripe and its bark essential oil is a potential source of alpha-bisabolol. The present study aimed to elucidate the antinociceptive and antipruritic properties of the essential oil of V. arborea Baker (EOVA) in mice. MATERIALS AND METHODS The antinociceptive activity was assessed using the capsaicin,...

2016
Sandip P Patil ML Pardeshi

In the present study, the effect of aqueous extract of Momordica dioica, aqueous extract of Myrica esculenta and ethanolic extract of Euphorbia hirta a lone and in combinat ion on h istamine induced bronchospasm in guinea p ig, milk induced leukocytosis and eosinophilia in mice and on antipruritic activity in mice was done. In the animal model o f h istamine induced bronchospasm , all plant sho...

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