Introduction: Inappropriate initial antimicrobial therapy leads to higher mortality in patients with bloodstream infection. This study aimed to evaluate the relationship between risk factors, etiology and antimicrobial therapy on mortality rates of patients with bloodstream infection. Methods: Between January 2016 to December 2016, 167 patients with bloodstream infection were prospectively eval...

Objective The standard of hygiene in daily life and hospitals can be increased by the use of new antimicrobial fibers, which diminish the danger of pathogenic bacteria. In this study, the antimicrobial effect of special fibers on some staphylococcus isolates was investigated. Materials and Methods The antimicrobial effect of special type of fibers produced in Isfahan Poly Acryl Plant on thre...

The present study addressed the effect of microcirculatory blood flow on the ability of ciprofloxacin to penetrate soft tissues. Twelve healthy male volunteers were enrolled in an analyst-blinded, clinical pharmacokinetic study. A single intravenous dose of 200 mg of ciprofloxacin was administered over a period of approximately 20 min. The concentrations of ciprofloxacin were measured in plasma...

Pharmacodynamics is commanding a greater role in the study of antibiotic efficacy and determination of dosing regimens. The simple measurement of serum, tissue, and body fluid antibiotic concentration do not provide sufficient information concerning the rate of pathogen killing at the site of any postantibiotic effects that may be occurring. This article discusses the pharmacokinetic and pharma...

Mastitis, or inflammation of the mammary gland, is the most common and expensive illness of dairy cows throughout the world. Although stress and physical injuries may give rise to inflammation of the udders, infections by bacteria or other microorganisms remain the major cause, and infusion of antibiotics is the main treatment approach. However, the increased emergence of multidrug-resistant pa...

The purpose of this study is to carry out comparative in vitro study of bactericidal effect of antimicrobial drugs used in modern endodontics against some basic microbial agents of periodontitis. Using the agar diffusion method (experiment with sterilized disks and wells) antimicrobial effect of five antimicrobial agents used in endodontics is evaluated: Rockle, Cresophene, I2/KI, Cupral, Ca(OH...

Antimicrobial use in animals is known to contribute to the global burden of antimicrobial resistance. Therefore, it is critical to monitor antimicrobial sales for livestock and pets. Despite the availability of veterinary antimicrobial sales data in most European countries, surveillance currently lacks consumption monitoring at the animal species level. In this study, alternative methods were i...

BACKGROUND Antimicrobial resistance is particularly harmful to infectious disease management in low-income countries since expensive second-line drugs are not readily available. The objective of this study was to implement and evaluate a computerized system for surveillance of antimicrobial resistance at a tertiary hospital in Tanzania. METHODS A computerized surveillance system for antimicro...