Antimicrobial resistance has emerged as an important variable influencing patient mortality and overall resource use in the hospital setting (1). Intensive care units (ICUs) worldwide are faced with increasingly rapid emergence and spread of antibiotic-resistant bacteria. Both antibiotic-resistant Gramnegative and Gram-positive bacteria are reported as important causes of hospital-acquired infe...

The efficacies of many antimicrobial peptides are greatly reduced under high salt concentrations, therefore limiting their use as pharmaceutical agents. Here, we describe a strategy to boost salt resistance and serum stability of short antimicrobial peptides by adding the nonnatural bulky amino acid β-naphthylalanine to their termini. The activities of the short salt-sensitive tryptophan-rich p...

BACKGROUND Knowledge on antimicrobial drug resistance and genetic characteristics of Neisseria gonorrhoeae isolates circulating in India, Pakistan, and Bhutan is sorely lacking. In this paper, we describe the prevalence of antimicrobial resistance and molecular characteristics of N. gonorrhoeae isolates from India, Pakistan, and Bhutan in 2007-2011. METHODS Antimicrobial susceptibility and β-...

resistance to oxyimino cephalosporins antibiotics in enterobacteriaceae is primarily done by the extended spectrum β-lactamases (esbls). clear identification of risk factors for esbl-producing infections is necessary. therefore, efficient strategies can be developed to decrease outbreak of these infections. the aim of this study was to determine the antibacterial susceptibility and esbls patter...

Metallo-β-lactamase-producing Pseudomonas aeruginosa (MPPA) is an important nosocomial pathogen that shows resistance to all β-lactam antibiotics except monobactams. There are various types of metallo-β-lactamases (MBLs) in carbapenem-resistant P. aeruginosa including Imipenemase (IMP), Verona integron-encoded metallo-β-lactamase (VIM), Sao Paulo metallo-β-lactamase (SPM), Germany imipenemase (...

Background and Objectives This study was undertaken to characterize antimicrobial resistance phenotypes and genes encoding extended spectrum β-lactamases (ESBLs) in Klebsiella isolated from retail chicken meat in Mansoura, Egypt. Materials and Methods Three hundred sixty chicken meat samples from 120 eviscerated chicken carcasses (3 cuts each) collected randomly from local retail chicken shop...

BACKGROUND/AIM Virulent Pseudomonas aeruginosa. is frequently life-threatening and often challenging to treat, and the emergence of multidrug-resistant isolates presents a critical problem for patients. The aim of the study was concerned with molecular analysis of the virulence factors and antimicrobial resistance profile of multidrug-resistant P. aeruginosa (MDRPA). MATERIALS AND METHODS Out...

Commonly, antiseptic agents are used as preventive agents while antimicrobial agents are used for therapeutic purposes. Cross-resistance of antiseptic agents and antimicrobial agents is not thoroughly studied. Theoretically, it is possible since antiseptic agents sometimes act at the same receptors or pathways as the antimicrobial agents to curtail the infections. Due to this, exposure to antis...

Commonly, antiseptic agents are used as preventive agents while antimicrobial agents are used for therapeutic purposes. Cross-resistance of antiseptic agents and antimicrobial agents is not thoroughly studied. Theoretically, it is possible since antiseptic agents sometimes act at the same receptors or pathways as the antimicrobial agents to curtail the infections. Due to this, exposure to antis...

Commonly, antiseptic agents are used as preventive agents while antimicrobial agents are used for therapeutic purposes. Cross-resistance of antiseptic agents and antimicrobial agents is not thoroughly studied. Theoretically, it is possible since antiseptic agents sometimes act at the same receptors or pathways as the antimicrobial agents to curtail the infections. Due to this, exposure to antis...