The rationale of the following work has been given in preceding papers (3, 4, 6). According to the views there proposed, it could be expected that antimetabolites of l,2-dimethyl-4,5-diaminobenzene would be harmful to spontaneous mammary tumors of mice but not toxic to the animal as a whole. Provided that such an antimetabolite was not rapidly destroyed or excreted by the animal, the discovery ...

BACKGROUND Maintaining homeostasis is the biological function of negative feedback, a process that plays a well-understood role in the biochemistry of antimetabolite drugs. An equally important property of living systems--the ability to respond to external stimuli by switching rapidly from one state to another--is mediated by positive feedback. Kinetic analysis of multi-enzyme biochemical pathw...

Historically, the most useful medicinal agents have been obtained by empirical screening or by the chemical modification of compounds of known activity in the hope of making them more effective. To these approaches a new one was added in recent years-antimetabolites. An antimetabolite may be defined as a compound bearing structural resemblance to a metabolite and capable of being attached to th...

Studies have been made previously on the ef fect of ethionine on the free amino acids in the livers of tumorous and nontumorous rats of the Long-Evans (6, 8), Sprague-Dawley (13), and Wistar (9) strains. Attempts at dual blocking, with pairs of antimetabolites, have also been re ported (12). The observation that certain amino acids may function as antimetabolites in inhibiting tumor growth (3, ...

Vulvovaginitis with Candida spp. is the most common infection in women and rate increased during pregnancy. Antifungal prescription pregnant continues to present challenges decision must balance risk of fetal toxicity benefits fetus mother. Starting from idea that clotrimazole recommended antifungal candidal vaginitis pregnancy, we tested sensitivity different species other azoles, polyenes, an...

Nucleoside analogues which show antimetabolic activity in cells have been successfully used in the treatment of various tumors. Nucleosides such as 1-beta-D-arabinofuranosylcytosine (araC), 6-mercaptopurine, fludarabine and cladribine play an important role in the treatment of leukemias, while gemcitabine, 5-fluorouracil and its prodrugs are used extensively in the treatment of many types of so...

Overman and Woltz (3) indicated that amino acid antimetabolites applied to tile soil suppressed reproduct ion of Paratrichodorus minor (Trichodorus christiei) and root galling caused by Meloidogyne incognita on tomatoes. Eight DL-amino acid antimetabolites similarly decreased the population of Aphelenchoides ritzemabosi on Lucerne, whereas DL-alanine suppressed the populat ion of Heterodera spp...