Drug interactions can occur when two or more medications are simultaneously given, and one drug increases decreases the effectiveness of other. Azole antifungal agents show a wide range with other drugs. Failure to recognize drug–drug interaction may produce harm patient, including enhanced toxicity concomitantly administered medication. Most azole antifungals pharmacokinetic type. This article...

conclusions in conclusion we can state that rhodotorula have considerable distribution in critical wards and could be regarded as important invasive mycosis causative agents. in addition all tested antifungal agents, except fluconazole, are effective against rhodotorula species in vitro. materials and methods six hundred samples were collected from different areas of two educational hospitals o...

In order to develop new approaches to the treatment of the severe and usually fatal infections caused by Scedosporium spp., the in vitro antifungal activities of four novel triazoles (posaconazole, ravuconazole, voriconazole, and UR-9825) and some current antifungals (amphotericin B, ketoconazole, itraconazole, and nystatin) were determined. The latter group was clearly ineffective against the ...

Candida albicans is a pathogenic member of the human oral and gastrointestinal microbiota. Biofilms of C. albicans form on indwelling devices, such as catheters and heart valves, and recent evidence suggests that biofilms also form on the mucosal surfaces of the mouth and vagina. Biofilm infections of prosthetic devices are untreatable by antifungals and infections of the mucosa are frequently ...

In this issue of Chemistry & Biology, Cokol and colleagues report a systematic study of drug interactions between antifungal compounds. Suppressive drug interactions occur more frequently than previously realized and come in different flavors with interesting implications.

QUESTION My pregnant patients often present with symptomatic vaginal yeast infections. Are the medications commonly used for the management of yeast infections safe to use during pregnancy? ANSWER Existing data indicate that exposure to oral and topical antifungals, topical antiseptics, or corticosteroids during pregnancy is not associated with increased risk of major malformations. Topical a...

The objective of this study was to determine the antimicrobial resistance of 319 yeast strains and 168 algae strains isolated from cows` mastitic milk. The in vitro susceptibility to 10 antifungals and 10 antibiotics was examined by disc diffusion method. Above 75% of yeast strains were resistant to amphotericin B, 66% to fluconazole, and 40% to pimaricin and itrakonazole. Algae strains were re...

The efficacy and safety of amorolfine 5% nail lacquer in combination with systemic antifungal agents in the treatment of the onychomycosis were evaluated. According to our meta-analysis, combination treatment of amorolfine 5% nail lacquer and systemic antifungals can result in higher percentage of complete clearance of onychomycosis. It showed that the experimental combination group was more ef...

A recently published retrospective study by Posteraro et al. [1] investigated the use of (1–3)-β-D-glucan (BDG) as a strategy for antifungal drug administration in patients at high risk of candidemia. The strategy consisted of the administration of antifungals (anidulafungin in most cases) to septic patients with a Candida score ≥ 3 and a positive BDG result (≥80 pg/ml). This untargeted strateg...