Candida albicans is the most common cause of hematogenously disseminated candidiasis, and this disease is particularly prevalent in immunocompromised patients. The mortality of invasive candidiasis remains 40% to 50% even with the proper treatment with current antifungal drugs. Recently, with the better understanding of host-fungus interactions, notable progress has been made in antifungal vacc...

In the aim of searching for new antifungal products from marine origin, we have isolated a sphingosine derivative, (9Z)-2-amino-docos-9-ene-1,3,13,14-tetraol (Haliscosamine) from the Moroccan sea sponge Haliclona viscosa using bio-guided (antifungal) HPLC methods. The molecular structure of this compound was elucidated by spectrometric techniques IR, UV, MS and NMR. The isolated metabolite show...

Candida is an important opportunistic fungal pathogen, especially in biofilm associated infections. The formation of a Candida biofilm can decrease Candida sensitivity to antifungal drugs and cause drug resistance. Although many effective antifungal drugs are available, their applications are limited due to their high toxicity and cost. Seeking new antifungal agents that are effective against b...

Introduction The oral cavity is a habitat for a large number of microorganisms which coexist with one another as normal microbiota. Candida species are ovoid budding yeast like fungi. The organism is a normal commensal of humans found on skin and throughout gastrointestinal tract. Poor oral hygiene, high carbohydrate diet, nutritional deficiencies, diabetes mellitus, dental prostheses, heavy ci...

Dandruff caused by Malassezia spp is controlled by antifungal agents. In the present study four medicinal plantsTerminalia bellerica, Terminalia chebula, Emblica officinalis and Lantana camarawere selected to check their antifungal activity. Their efficacy was tested using different concentrations of extracts in various solvents. The antifungal activity of the plant extracts was determined by w...

We report a rapid acquisition of echinocandin resistance after 12 days of micafungin treatment, without prior exposure, in a patient with peritoneal candidiasis due to C. glabrata. Isolates recovered before and after treatment were compared by multilocus sequence typing. Results of antifungal susceptibility testing and FKS mutations were reported. The interest of repeating antifungal susceptibi...

The in vitro antifungal activities of few novel 4-aminoantipyrine derived Schiff bases and their metal complexes were tested against fungi such as Aspergillus niger, Fusarium solani, Culvularia lunata, Rhizoctonia bataicola and Candida albicans. All the metal complexes showed stronger antifungal activities than the free ligands. The synthesized compounds were subjected to molecular docking stud...

Dermatophyte fungi are the etiologic agents of skin infections commonly referred to as ringworm. These infections are not dangerous but as a chronic cutaneous infections they may be difficult to treat and can also cause physical discomfort for patients. They are considered important as a public health problem as well. No information is available regarding the efficacy of antifungal agents again...

Trials were conducted to compare a modification of a commercial medium with the 2 media currently used at the Veterinary Research Institute, Onderstepoort, for the isolation of Trichomonas foetus. An antifungal agent was also added to the medium. Results obtained proved the modified medium to be more reliable for the isolation of T. foetus than the other 2, and the addition of antifungal more e...