background: lactic acid bacteria (lab) isolated originally from sourdough are probably the best candidates as biopreservatives, because they are well adapted to the non-aseptic conditions in sourdough fermentation. the aim of the present study was to study antifungal properties of a dominant endogenous lab isolated from whole barley sourdough. methods: whole barley flour from a mixture of barle...

Introduction Systemic Antifungal therapy (SAT) of invasive candidiasis (IC) needs to be started immediately upon clinical suspicion. Controversies exist then about potential harms from antifungal de-escalation (DE).(1) In cases of documented IC, early DE to fluconazole is recommended by US guidelines but discouraged in EU guidelines. In non-documented IC, no data are available to guide SAT DE. ...

Problem statement: A number of studies have recently conducted to identify novel and potent antifungal components from natural products. One of the reasons is to overcome the antifungal resistant developed against most of commercially available drugs. Studies confirmed that mung beans have increased phenolic compounds and enhanced defenses during germination. Approach: We hypothesized that anti...

Fungal infections are a group of diseases spread all over the world with an extremely high morbidity. Worryingly, although several pathogenic fungi were found to develop resistance towards traditional therapy, research towards the discovery of novel antimycotic agents is very limited. Considering the promising results obtained with the ferrocene-based drug candidates Ferroquine and Ferrocifen a...

Ring-whizzing was investigated by hybrid DFT methods in a number of polyene-Pt(diphosphinylethane) complexes. The polyenes included cyclopropenium(+), cyclobutadiene, cyclopentadienyl(+), hexafluorobenzene, cycloheptatrienyl(+), cyclooctatetraene, octafluorooctatetraene, 6-radialene, pentalene, phenalenium(+), naphthalene and octafluoronaphthalene. The HOMO of a d(10) ML2 group (with b2 symmetr...

Pyrazine derivatives are important class of compounds with diverse biological and cytotoxic activities and clinical applications. In this study, B3 p 86 / 6 – 31 + + G * was used to compute and map the molecular surface electrostatic potentials of a group of substituted amides of pyrazine-2-carboxylic acids to identify common features related to their subsequent cytotoxicities. Several statisti...

Relatively simple and rapid procedures have been developed for evaluating the local efficacy of vaginal antifungal agents in vivo in a vaginal candidiasis model in ovariectomized rats. The results of this investigation indicate that the model and methods described are quite suitable for screening potential antifungal substances and for assessing the chemotherapeutic effectiveness of new antifun...

Natural plant extracts / products have the potential as safe alternatives for chemical fungicides in plant disease management. Methanol and pure methanol: water (50:50 v/v) extracts of peppermint, lavandula, eucalyptus, datura and nettle were screened for their antifungal activity against Alternaria sesami, the causal agent of Alternaria leaf spot of sesame at 5, 10 and 15% concentrations in Sh...

Antifungal potential of aqueous extracts of forty plants of different families were tested against Fusarium oxysporum f.sp. ciceri causal agent of wilting of chick pea. Among forty plant species tested aqueous extract of Chenopodium ambrosioides has recorded significant antifungal activity against the test fungi. Solvent extracts viz. petroleum ether, benzene, chloroform, and methanol and ethan...