background: valproic acid (vpa) is an effective antiepileptic drug widely used worldwide. despite several studies indicating the usefulness of intravenous l-carnitine in the treatment of vpa poisoning, this drug is not readily available in iran. the aim of this study was to determine whether supportive care without antidote would result in acceptable outcomes in vpa poisoned patients. materials...

Intravenous immune globulin (IVIG) has proved beneficial for severe immunologically related cutaneous adverse reactions. We report a child with severe antiepileptic drug hypersensitivity syndrome who was successfully treated with IVIG. IVIG should be considered in the pharmacologic armamentarium of severe antiepileptic drug hypersensitivity syndrome. antiepileptic drugs, hypersensitivity, immun...

PURPOSE To determine the percentage of children whom first-line antiepileptic drug treatment failed and the specific reasons for the treatment failure in newly diagnosed epilepsy. METHODS Hospital records were reviewed for 225 children who were newly diagnosed with epilepsy, started on the first antiepileptic drug, and then monitored for approximately 4.2 years. RESULTS Of the 225 patients ...

The management of the pregnant epileptic requires close cooperation between the neurologist and obstetrician. To prevent complications, knowledge is required about the natural history of epilepsy during pregnancy, the possible teratogenic effects of antiepileptic drugs, and changes in their absorption, biotransformation, and excretion. Close plasma antiepileptic drug monitoring is required beca...

BACKGROUND We investigated the impact of the type of neurological disorder on the required propofol dose for anesthesia and the time to emerge from anesthesia during dental treatment in patients with autism (AU), cerebral palsy (CP), and intellectual disability (ID), some of whom also had epilepsy. METHODS We studied 224 patients with a neurological disorder who underwent dental treatment und...

background: diminished libido and sexual dysfunction are unusually common among male epileptic patients. the most important etiologic factor may be antiepileptic drugs (aeds)-induced androgen deficiency. we compared reproductive hormone levels among men with epilepsy taking various aeds and normal controls. methods: subjects were 59 male epileptic patients who aged 24 ± 5 years. they had been r...