The article highlighted in this issue is "Dizocilpine Improves Beneficial Effects of Cholinergic Antagonists in Anticholinesterase-Treated Mice," by Andrzej Dekundy, Rafal M. Kaminski, and Waldemar A. Turski (pp. 289-295). It explores the relationship between cholinergic and N-methyl-D-aspartate (NMDA) receptors as mediators of anticholinesterase toxicity. The following review summarizes these ...

Is it always necessary to antagonize residual neuromuscular block? Do children differ from adults? Use of an anticholinesterase at the end of surgery, to antagonize residual neuromuscular block induced by a non-depolarizing drug, is commonplace; it is easy to forget that such drugs were not always given routinely. When the clinical use of " Intocostrin " (a biologically standardized extract of ...

FORTY-FIVE years after Beecher and Todd 1 first described an increase in mortality associated with the use of D-tubocurarine, anesthesiologists are still learning how best to use neuromuscular blocking agents (NMBAs) and their antagonists. Practices regarding antagonism of residual neuromuscular block vary based on the country of practice, type of anesthetic practice, and individual clinician p...

alzheimer’s disease (ad) is a neurodegenerative disease that was characterized with deposit of beta amyloid (aβ) aggregate in senile plaque. oxidative damage to neurons and loss of cholinergic neurons in forebrain region are observed in this disease. melissa officinalis is a medicinal plant from lamiaceae family, used traditionally in the treatment of cognitive disorders. it has cholinomimetic ...

Cyphomandra betacea is one of the underutilized fruits which can be found in tropical and subtropical countries. This study was conducted to determine the antioxidant activity and phytochemical contents in different parts (i.e., flesh and peel) of the fruits. Antioxidants were analyzed using DPPH and ABTS free radical scavenging assays as well as FRAP assay. Anticholinesterase activity was dete...

BACKGROUND Nowadays, owing to medicinal plants as a candidate to obtain promising new medicinal agents, there is a renewed interest in the use of these natural sources for drug development. OBJECTIVE In the present study, we aimed to assess the anticholinesterase, antioxidant, and neuropotective effects of Tripleurospermum disciforme and Dracocephalum multicaule extracts. MATERIALS AND METH...