to side, and of moving his toes. The skin remained quite sensible to the touch, the functions of the primae viae and urinary organs continued natural, and he had neither headache nor giddiness". Nearly four months from the beginning of his illness his clinical state was more or less unchanged. " ... he could not without a great effort move even in a slight degree either the upper or the lower e...

A case of toxic psychosis due to antihistamine poisoning is described. The reversal of this state by physostigmine supports the contention that it is caused by an anticholinergic syndrome. The management of antihistamine poisoning is discussed.

We report two cases of unintentional poisoning with anticholinergic agents. The first patient, a 7-year-old girl, was prescribed four different medications by a general practitioner for treatment of abdominal colic and diarrhoea. All drugs had anticholinergic properties. The second patient, a 16-month-old boy, ingested his mother's cyproheptadine tablets. Both children presented with central an...

Lavender plants have been used for their cosmetic and biologic benefits for many centries. Extracts from Lavandula plants have been found to cause antimuscarinic effects by blocking sodium and calcium ion channels in in vitro and in vivo studies. We present a case of poisoning by ingestion of tea made from Lavender stoechas ( grass). The patient was admitted to our emergency department with sup...

Trihexyphenidyl or Artane® /Parkinane® is an anti-cholinergic drug belonging to the antimuscarinic class. It used in treatment of Parkinson’s disease and widely psychiatry for management extrapyramidal side effects neuroleptics. Its overdose leads a central peripheral anticholinergic syndrome. We report here case seven-year-old Senegalese boy who developed signs intoxication due accidental inge...

References 1. Ekbom K, Lindholm H, Ljungberg L: New dystonic syndrome associated with butyrophenone therapy. Z Neurol 1972; 202: 94–103 2. Yassa R, Nastase C, Cvejic J, Laberge G: The Pisa syndrome (or pleurothotonus): prevalence in a psychogeriatric population. Biol Psychiatry 1991; 29:942–945 3. Duggal HS, Sivamony S, Umapathy C: Pisa syndrome and atypical antipsychotics (letter). Am J Psychi...

Poisoning remains a major cause of hospital admission into the emergency department and intensive care unit. Proper diagnosis is the cornerstone for optimal management of poisoned patients. Since the definitive analytical confirmation of the nature of the toxicant involved in the poisoning cannot be rapidly obtained in the majority of healthcare facilities, diagnosis relies on the medical histo...

Scopolamine hydrobromide (hyoscine) is an antimuscarinic drug which is primarily used in the prophylaxis and treatment of motion sickness and as a premedication to dry bronchial and salivary secretions. In acute overdosage, the main clinical problem is central nervous system (CNS) depression. In Australia, tablets containing scopolamine hydrobromide 0.3 mg are available over the counter in pack...

In the opera Tristan und Isolde Richard Wagner reports the poisoning of Tristan and Isolde by a “love potion.” Shortly after ingestion of the potion, the protagonists declare their love, and both die during the opera. The opera has been extensively interpreted by psychoanalysts and musicologists, but, although at least Isolde’s death remains unexplained and might be due to the potion, the medic...