Fluctuations of lupus anticoagulant activity and anticardiolipin antibody titres were studied in 53 patients with systemic lupus erythematosus (SLE). The median study time was 26 months with a median number of 12 samples. Lupus anticoagulant was measured by the kaolin clotting time (KCT) and dilute Russell viper venom time (dRVVT) assays; anticardiolipin antibodies were assayed by an enzyme lin...

AIM This study aimed at evaluating the prevalence of high anticardiolipin antibody and lupus anticoagulant levels in women with histories of at least two miscarriages. METHODS The presence of high anticardiolipin antibody and lupus anticoagulant levels were evaluated in 52 patients with ages between 17 and 41 (mean 26.7 years old) who had histories of repeated miscarriages. RESULTS High ant...

background: antiphospholipid antibody syndrome (aps) can either occur as a primary syndrome or associated with other autoimmune diseases such as systemic lupus erythematosus (sle). anticardiolipin antibody (acl) of igg and/or igm isotype in blood, measured by a standardized elisa is the most acceptable laboratory criteria. aps igg isotype, particularly igg2 subclass is more strongly associated ...

Rabbit antiserum to cardiolipin, which is reactive with the polar head but not the nonpolar fatty acid moieties of cardiolipin, was used to explore the location of the polar head of cardiolipin in mitochondrial membranes. Only a few per cent of the cardiolipin in intact mitochondria from rat liver, blowfly flight muscle, Saccharomyces cerevisiae, and Neurospora and none of the cardiolipin in in...

Rabbit antiserum to cardiolipin, which is reactive with the polar head but not the nonpolar fatty acid moieties of cardiolipin, was used to explore the location of the polar head of cardiolipin in mitochondrial membranes. Only a few per cent of the cardiolipin in intact mitochondria from rat liver, blowfly flight muscle, Saccharomyces cerevisiae, and Neurospora and none of the cardiolipin in in...

background: severe preeclampsia is a quite well-known entity with high incidence of both maternal and fetal morbidity and mortality. although little is known about its etiology, inherited disorders of hemostasis and antiphospholipid syndrome have been postulated as common causes. the present study was conducted to evaluate the association of these two entities with preeclampsia in a group of ir...

BACKGROUND AND PURPOSE Antiphospholipid antibodies have been associated with ischemic stroke in some but not all studies. METHODS We performed a population-based case-control study examining antiphospholipid antibodies (anticardiolipin antibodies and lupus anticoagulants) using stored frozen sera and plasma in 160 cases and 340 controls enrolled in the Stroke Prevention in Young Women study. ...

SIR, We completely agree with Dr E N Harris that carrying out clotting assays to detect lupus anticoagulant is more difficult than an enzyme linked immunosorbent assay (ELISA) for anticardiolipin antibodies. Specialised laboratories are necessary, coagulation tests are time consuming, and improper preparation and handling of plasma samples strongly influence the results of lupus anticoagulant a...

A 23-year-old male was admitted to our hospital with complaints of shortness breath, grade-III, chest pain, and palpitation for the last 3 months. He had one episode hemoptysis months back. a known case primary antiphospholipid antibody syndrome (APS) bilateral chronic pulmonary thromboembolism thromboembolic hypertension (CTEPH) presence anticardiolipin antibody. The patient no history joint h...