Objective(s):The colorectal cancer stem cells (CSCs) with the CD133+ phenotype are a rare fraction of cancer cells with the ability of self-renewal, unlimited proliferation and resistance to treatment. Quercetin has anticancer effects with the advantage of exhibiting low side effects. Therefore, we evaluated the anticancer effects of quercetin and doxorubicin (Dox) in HT29 cancer cells and its ...

Saponins are glycosides with triterpenoid or spirostane aglycones that demonstrate various pharmacological effects against mammalian diseases. To promote the research and development of anticancer agents from saponins, this review focuses on the anticancer properties of several typical naturally derived triterpenoid saponins (ginsenosides and saikosaponins) and steroid saponins (dioscin, polyph...

Cancer is still one of the major causes of mortality in both developing and developed countries. At this time, in spite of intensive interventions, a large number of patients have poor prognosis. Therefore, the effort for finding new anticancer agents with better efficacy and lesser side effects has continued. According to the traditional recommendations and experimental studies, numerous medic...

Introduction: Drug-induced adverse effects are the major challenging issue in clinical setting of chemotherapy. Kidneys responsible for elimination many chemotherapeutic agents which makes them a common target effects. Nephrotoxicity is deleterious effect carrying great negative impact on body homeostasis and maintenance cellular functions.Aim: The present review aims to focus anticancer-induce...

background: marine natural products contain a wide range of bioactive compounds with therapeutic properties that have revealed crucial properties in the treatment of some diseases. some of these compounds have recently received considerable attention for drug discovery. in this study we examined the anti-angiogenic effect of saponin isolated from holothuria leucospilota (sea cucumber) through e...

A variety of nutritional supplements are commercially available for the potential therapeutic purpose for dogs and other domestic animals with cancers. However, the efficacy of these supplements on those cancer-bearing animals has not been verified and remains uncertain, due to the lack of the sufficient scientific studies/data. To address this important issue, we examined actual anticancer eff...

the biological activity and composition of the essential oil of sclerorhachis leptoclada rech. an endemic species from northeast of iran was studied. the essential oil was isolated from the aerial flowering parts of the plant and analyzed by gc and gc-ms. fifty-four compounds accounting for 95.9% of the total oil were characterized. the main constituents were (e)-nerolidol (14.5%), terpinen-4-o...