Synthesis and biological properties of a number of amides of polyene macrolide antibiotic aureofacin obtained in the reaction of the antibiotic with various glycine esters are described.

OBJECTIVE To discuss the altered pharmacokinetic properties of selected antibiotics in critically ill patients and to develop basic dose adjustment principles for this patient population. DATA SOURCES PubMed, EMBASE, and the Cochrane-Controlled Trial Register. STUDY SELECTION Relevant papers that reported pharmacokinetics of selected antibiotic classes in critically ill patients and antibio...

The dielectrophoretic collection spectra of antibiotic-sensitive and antibiotic-resistant strains of Staphylococcus epidermidis have been determined. These indicate that in the absence of antibiotic treatment there is a strong similarity between the dielectric properties of sensitive and resistant strains, and that there is a significant difference between the sensitive strains before and after...

During the course of screening for new antibiotics from rare actinomycetes in our laboratory, a rare actinomycete initially designated as strain A-3416 was found to produce an antibiotic with strong activity against staphylococci resistant to various antibiotics. From its unique physicochemical properties, it was judged to be a new antibiotic and named antibiotic AB-64. In this paper, taxonomic...

This session will focus on the fate and ecotoxicological effects of antibiotics, antibiotic resistance (AR) development and transfer in the environment and implications for human health. Specifically, we use the term antibiotic to include pharmaceutical agents with antibacterial properties. The scope of the session also extends to other chemical agents that can co-select for antibiotic resistan...