The emergence of drug resistance in Mycobacterium tuberculosis is a major challenge in tuberculosis treatment and control. In addition, multidrug resistance (MDR) and, more broadly, extensive drug resistance (XDR) have hampered treatment with common antibiotics. Thus, an herbal medicine containing antimicrobial capability can be a good alternative to antituberculosis drugs. In this study, we re...

The resistance of antimicrobials has become a global hazard with the irrational use of antibiotics. Infection of drug-resistance bacteria seriously threatens human health. Currently there is an urgent need for the development of novel antimicrobial agents with new mechanisms and lower levels of toxicity. In this paper, a series of (S,Z)-4-methyl-2-(4-oxo-5-((5-substitutedphenylfuran-2-yl) methy...

Bacteria may be resistant to antibacterial drugs because of some alterable property of the cell or the environment ('phenotypic resistance') or some alteration of the usual genetic properties of the cell ('genotypic resistance'). Genotypic resistance can be mediated by a mutation of the bacterial chromosome or the infection of the cell by an extrachromosomal element, e.g. an R factor. The prope...

Objective To assess the application of antibacterial agents, alongside pathogen prevalence and Pseudomonas aeruginosa drug resistance, with the aim of understanding the impact of inappropriate antibacterial use. Methods This retrospective study assessed bacteria from wounds, catheters, blood, faeces, urine and sputum of hospitalized patients in burn wards between 2007 and 2014. The intensity of...

Bacterial antibiotic resistance is an emerging public health problem worldwide; therefore, new therapeutic strategies are needed. Many studies have described antipsychotic compounds that present antibacterial activity. Hence, the aims of this study were to evaluate the in vitro antibacterial activity of antipsychotics belonging to different chemical families, to assess the influence of their as...

The resistance of antimicrobials has become a global hazard with the irrational use of antibiotics. Infection of drug-resistance bacteria seriously threatens human health. Currently there is an urgent need for the development of novel antimicrobial agents with new mechanisms and lower levels of toxicity. In this paper, a series of (S,Z)-4-methyl-2-(4-oxo-5-((5-substitutedphenylfuran-2-yl) methy...

Increasing resistance to antibacterials is a major public health problem. Antibacterial use is considered to be the main selective pressure driving this resistance, and the rate at which resistance develops has been shown to be associated with drug consumption. It has been suggested that reductions in the development of resistance will only result from significant changes in antibacterial use. ...

Given the problem of increasing antimicrobial--especially antibacterial--drug resistance and the paucity of new agents, it is sensible to consider alternative approaches to infection control to aid in conservation. Photoantimicrobials are highly active agents, regardless of the conventional drug resistance status of the intended organism. Their use in infection control, via topical or local tre...