نتایج جستجو برای: antibacterial drug
تعداد نتایج: 625588 فیلتر نتایج به سال:
Very few chemically novel agents have been approved for antibacterial chemotherapies during the last 50 yr. Yet new antibacterial drugs are needed to reduce the impact on global health of an increasing number of drug-resistant infections, including highly drug-resistant forms of tuberculosis. This review discusses how genetic approaches can be used to study the mechanism of action of whole-cell...
Background & Aim: The use of bone scaffolds is one of the new and efficient techniques for repairing bone defects that provide a suitable platform for cell proliferation and growth to repair the target tissue. One of the most important causes of failure of transplants and surgical procedures is the invasion of bacteria at the site of the complication and the development of severe infection. The...
introduction and aims: acinetobacter baumannii in recent decay has become an increasing concern in hospitals for its ability to acquire antibiotic resistance determinants rapidly and becoming resistant to almost all of the antibiotic classes. borage (echium amoenum fisch. et mey), is a wild annual plant of boraginaceae family, grows in northern mountains of iran and has largely been used by ir...
Aim: In this study we aimed to search the antibacterial effect of the drugs with active ingredients of Pelargonium sidoides on different bacterial species isolated from the throat cultures of patients with upper airway infection. Methods: Antibacterial activity on 72 Streptococci, 48 Stapyhlococcus, 32 Neisseriae spp, 20 Moraxella catarrhalis, and 20 Haemophilus influenzae was evaluated by usin...
Increasing resistance to every major class of antibiotics and a dearth of novel classes of antibacterial agents in development pipelines has created a dwindling reservoir of treatment options for serious bacterial infections. The bacterial type IIA topoisomerases, DNA gyrase and topoisomerase IV, are validated antibacterial drug targets with multiple prospective drug binding sites, including th...
Cell membrane is at the frontline of the battle between pathogenic microbe and host. A thorough understanding of bacterial membrane is fundamental to tackle infection disease. Membrane mimetic provides a powerful tool for mechanistic investigation of drug-membrane interaction. Herein, we summarized major features of bacterial and mammalian cell in context of antibacterial therapy. Many details ...
objective: intravascular catheter-associated infection has been increasing hospitalization in post-surgery patients mainly due to microbial colonization of the catheter surface and formation of a superficial biofilm layer. the present study is aimed in developing an effective antibacterial device which can prevent colonization of organisms by modification of catheter. methods: in the present st...
one of the applications of nanotechnology is use of carbon nanotubes for the targeted delivery of drug molecules. to demonstrate the physical and chemical properties of biomolecules and identify new material of drug properties, the interaction of carbon nanotubes (cnts) with biomolecules is a subject of many investigations. cnts is a synthetic compound with extraordinary mechanical, thermal, el...
Bismuth (V) was incorporated in chloramphenicol and streptomycin keeping in view of finding new antibiotics. Formed complex was evaluated for their antibacterial and cell viability activity in mice. Murine peritoneal macrophage cell lines RAW 264.7 were used for in vitro antibacterial and cytotoxicty studies of various synthesized compounds. Bactericidal activity was assessed by Minimum inhibit...
BACKGROUND The rising drug resistance in pathogenic bacteria and inefficiency of current antibiotics to meet clinical requirements has augmented the need to establish new and innovative approaches for antibacterial drug discovery involving identification of novel antibacterial targets and inhibitors. Being obligatory for bacterial growth, essential gene products are considered vital as drug tar...
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