We report on the activities of a broad spectrum antimicrobial compound,nitropropenyl benzodioxole (NPBD) which are of relevance to its potential as an anti-infective drug. These investigations support the proposal that a major mechanism of NPBD is action as a tyrosine mimetic, competitively inhibiting bacterial and fungal protein tyrosine phosphatases (PTP). NPBD did not affect major anti-bacte...

Background: Avian pathogenic Escherichia coli (APEC), which is the causative agent of colibacillosis, harbors several putative virulence genes. An important trait of APEC for both poultry and public health is antibiotic resistance. Objectives: In the present study, some potential virulence genes of APECs isolated from Northeast of Iran and their resistance to the quinolones antibiotics were stu...

The intractability of bacterial resistance presents a dilemma for therapies against Staphylococcus aureus (S. aureus) infection. Effective anti-virulence strategies are urgently needed, reflecting the proliferation of resistant strains. Inhibitors of sortase A (SrtA), enzymes that anchor virulence-related surface proteins, are regarded as promising candidates for countermeasures against bacteri...

as the host plants based on their physical and chemical characteristics can affect virulence of microbial control agents on the target pest and its natural enemies, therefore in the current study, the virulence of beauveria bassiana tv isolate at concentration 107 conidia/ml was evaluated against t. urticae female adults, on three different host plants; tomato, cucumber and strawberry. spray to...

Quorum sensing (QS) is a global gene regulatory mechanism in bacteria for various traits including virulence factors. Disabling QS system with anti-infective agent is considered as a potential strategy to prevent bacterial infection. Mangifera indica L. (mango) has been shown to possess various biological activities including anti-QS. This study investigates the efficacy of leaf extracts on QS-...

"e Gram-negative Pseudomonas aeruginosa bacterial pathogen is reputed for its resistance to multiple antibiotics, and this property is strongly associated with the development of biofilms. Bacterial biofilms form by aggregation of microorganisms on a solid surface and secretion of an extracellular polysaccharide substances that acts as a physical protection barrier for the encased bacteria. In ...

introduction : the aim of this in vitro study was to evaluate the antimicrobial activity of four intracanal medicaments on enterococcus faecalis (e. faecalis). methods and materials: fifty extracted single-rooted human teeth were prepared with standard method. after contaminating the canals with e. faecalis , the samples were divided into one control and four experimental groups ( n =10). the t...

background pain experience makes a serious anxiety for both patient and clinician before and after root canal treatment. pain is a complex psychophysiologic phenomenon. objectives the aim of this randomized control trial study was to evaluate the analgesic effect of odontopaste® and a corticosteroid containing compound medicament between root canal therapy appointments. materials and methods on...

background: avian pathogenic escherichia coli (apec), which is the causative agent of colibacillosis, harbors several putative virulence genes. an important trait of apec for both poultry and public health is antibiotic resistance. objectives: in the present study, some potential virulence genes of apecs isolated from northeast of iran and their resistance to the quinolones antibiotics were stu...