development of phytotherapies aimed at angiogenesis inhibition, in combination with classical anti-cancer therapies, is among the most intensively studied approaches for treatment of cancer. epidemiological and animal studies have indicated that consumption of allium species like shallot is associated with a reduced risk of cancer development. as a continuation of our efforts to study and chara...

This study aimed to investigate the effect of hypoxic preconditioning (HPC) on primary retinal ganglion cell (RGC) survival and associated mechanism, including role vascular endothelial growth factor (VEGF). Retinas were separated from enucleated eyeballs Sprague–Dawley rats postnatal days 1–4. RGCs harvested using an immunopanning-magnetic separation system maintained for 24 h in a defined med...

Anti-angiogenesis is the therapeutic strategy designed to disrupt vascular supply and starve tumors of nutrients oxygen. This achieved mainly by blocking endothelial growth factor (VEGF) actions, as VEGF signaling pathway considered main angiogenesis promoter active in tumor microenvironment (TME) under hypoxic conditions. A total 16 anti-angiogenic agents, including anti-VEGF antibodies, recep...

diabetic macular edema (dme) is an important cause of blindness in the working population and is currently challenging to treat. current interventions include focal laser or intravitreal injections. this article outlines a new treatment protocol based on the concept that peripheral ischemia is the introduction to angiogenesis, that will ultimately gather its momentum at the fovea. performing ex...

Decades of research on vascular endothelial growth factor (VEGF) have reached fruition with the recent development of intravitreal anti-VEGF treatments for exudative age-related macular degeneration. VEGF is a critical regulator of angiogenesis and vascular permeability with diverse roles, both pathological and physiological, during development and adulthood. The aim of this article is to revie...

Current therapies that target vascular endothelial growth factor (VEGF) have become a mainstream therapy for the management of diabetic macular oedema. The treatment involves monthly repeated intravitreal injections of VEGF inhibitors. VEGF is an important growth factor for many retinal cells, including different types of neurons. In this study, we investigated the adverse effect of multiple in...

Objective(s): Blocking of vascular endothelial growth factor (VEGF) plays a pivotal role in inhibition of metastasis and is a target for development of anti-angiogenic agents. In this study, a peptide-based vaccine was designed and its potential for induction of humoral immune responses, generation of neutralizing antibodies, inhibition of tumor growth and metastasis w...