Xanthine oxidase is a key enzyme responsible for hyperuricemia, a pre-disposing factor for Gout and oxidative stress-related diseases. Only two clinically approved xanthine oxidase inhibitors Allopurinol and Febuxostat are currently used for treatment of hyperuricemia. However, owing to their side effects there is a need for new non-purine-based selective inhibitors of xanthine oxidase. In the ...

luteolin is a flavone in medicinal plants as well as some vegetables and spices. it is a natural anti-oxidant with less pro-oxidant potential but apparently with a better safety profile. the purpose of this study was to investigate the molecular mechanism of luteolin-mediated apoptosis of mg-63 human osteosarcoma cells. mtt assay kit was employed to evaluate the effects of luteolin on mg-63 cel...

Many herbs have been used as therapeutics in Korean traditional medicine. In view of their clinical indications, anti-oxidant activity may contribute to their pharmacological effects. However, anti-oxidant information on these plants has not been available. In this study, seventy herbs which have been used in Korean traditional medicine were selected and screened for anti-oxidant activity using...

The present study was aimed to enzymatic antioxidants (superoxide dismutase, catalase, polyphenol oxidase), nonenzymatic (saponin, flavonoids, ascorbic acid and tannin), anti-oxidant ability assays (total anti-oxidant, hydroxyl radical scavenging ability, reducing power activity, inhibition of lipid peroxide formation, DPPH activity metal chelating assay) in I. marginata leaves whole plant. res...

Here, we investigated the anti-oxidant and anti-aging effects of essential oils (EOs) from the leaves of Alpinia zerumbet (tairin and shima) in vitro and anti-melanogenic effects in B16F10 melanoma cells. The anti-oxidant activities were performed with 2,2-diphenyl-1-picrylhydrazyl (DPPH); 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS); nitric oxide; singlet oxyge...

We have analyzed the anti- or pro-oxidant effects of the flavonoid quercetin (QU) by evaluating, in U937 cell line, hydrogen peroxide (H(2)O(2)), superoxide anion reduced glutathione (GSH) content, mitochondrial membrane potential, DNA content, phosphatidylserine exposure on the outer face of the plasma membrane and cell viability. Polychromatic flow cytometry was used to evaluate in the same c...

objective(s): methylsulfonylmethane (msm) is a sulfur-containing compound found in a wide range of human foods including fruits, vegetables, grains and beverages. in this study the effect of msm pretreatment on acetaminophen induced liver damage was investigated. materials and methods: male sprague dawley rats were pretreated with 100 mg/kg msm for one week. on day seven rats were received acet...

The present study has been undertaken to evaluate In-vivo Anti–hyperglycemic and anti–oxidant activities of ethanolic Lantana camara leaves extract (LCE). was prepared by cold percolation process. Phytochemical screening indicates that the presence flavanoids, phenols, carbohydrates etc. Anti-hyperglycemic activity studied using Streptozotocin induced diabetes rat models. Glibenclamide used as ...