a 53-year-old male was referred to our department for refractory primary hypertension. despite high doses of 6 anti-hypertensive drugs, ambulatory monitoring of blood pressure (bp) revealed a mean bp of 160/90 mmhg. under local anaesthesia, renal denervation with radiofrequency was performed supported by high-resolution 3d angiography, which helped confirm the position of the applications in a ...

Background: Leptadenia hastata (L. Hastata) is a plant used for various diseases in Nigeria. This study evaluated the protective effects of L. hastate on the haematological and biochemical alterations in adrenaline-induced hypertensive rats. Methods: Twenty-five rats were divided equally into five groups (A-E). Groups A-D were given 0.5 mg/kg adrenaline, groups A and B were treated with 100 an...

PURPOSE To evaluate physicians' prescribing of anti-hypertensive drug combinations in a tertiary care setting in southwestern Nigeria, determine the degree of usage of Angiotensin Converting Enzyme (ACE) inhibitor-based combinations and identify specific points of intervention to improve outcomes of anti-hypertensive combination therapy. METHODS A cross-sectional retrospective drug use review...

High blood pressure produces ventricular dilation, variations in circumventricular organs and changes in the cerebrospinal fluid compositions. On the other hand, chronic hypertension in spontaneously hypertensive rats can cause changes in the integrity of the brain barriers: blood-cerebrospinal fluid barrier and blood brain barrier. The permeability of the brain barriers can be studied by using...

OBJECTIVE To assess prescriber adherence to standard anti-hypertensive treatment guidelines in South Africa, determine if supply data are useful indicators of drug use, and assess the cost implications of not complying with the guidelines. METHODS We undertook two studies: an analysis of records of the anti-hypertensive drugs supplied to all 54 public-sector hospitals with a hypertension clin...

apium graveolence has an small brown olyptical seed with pharmacological activity. to evaluate it's application in treatment of hypertension, 37 hypertensive patients (20 female, 17 male) with the age range of 45-65 were given 6 grams of powder of apium graveolence seed and then the blood pressures before and after the remedy were compared. before treatment, the mean systolic blood pressur...

1. Oral and intravenous administration of metoprolol to adult spontaneously hypertensive rats (SHR) with established hypertension lowered arterial blood pressure within 4 days of treatment. 2. Steady state plasma concentrations of metoprolol were similar to those of patients during anti-hypertensive treatment with this drug. 3. The neuroeffector function of portal veins of SHR treated orally fo...