Isoflavones are secondary phenolic metabolites found in most legumes. These compounds have important pharmacological significance such as anti-osteoporosis, anti-aging, and anti-cancer properties. Breast cancer is one of the common cancers women worldwide. Human epidermal growth factor receptor-2 (HER2) an target breast treatment. In this study, we evaluated ability sixty isoflavones to inhibit...

background: evidences show that aloe vera (a. vera), camellia sinensis, hibiscus sabdariffa and sophora alopecuroides may prevent gastric ulcer induced by non-steroidal anti-inflammatory drugs (nsaids). objective: to examine the protective potential of these plants against indomethacin-induced gastric ulcer in the rat. methods: saline, a. vera leaf gel powder and 70% alcoholic extracts of the o...

angiogenesis which is the recruitment of new blood vessels is a critical process in several chronic diseases and is an essential component of tumor or cancer progression. development of therapies aimed at inhibiting the angiogenesis, in combination with classical anti-cancer therapies, is among the most intensively studied approaches to treat the cancer. in this study the effect of chlordiazepo...

optimal reduction in blood pressure with antihypertensive agents helps to prevent microvascular and macrovascular complications of diabetes. the objective of the study was to evaluate the current utilization pattern of antihypertensive medications among patients with diabetes and coexistent hypertension as per the jnc seventh report guidelines. a cross-sectional survey was conducted among patie...

Nanoparticle-Drug Conjugates To combat pancreatic cancer with a dismal prognosis, self-assembled nanoparticle-drug conjugate is synthesized in article 2203011 by Peng Huang, Shijun Wen, Jiang Yang, and co-workers. Based on chemically-modified sulfated glycosaminoglycan derivatives, (NDC) efficiently encapsulates cyclodiaryliodonium NOX inhibitor from pooled screening, enabling hyaluronidase-act...

Drug Delivery Systems The systematic review in article 2300105 by Behnam Akhavan and co-workers examines poly ethylene glycol (PEG)-based hydrogels for cancer drug delivery, emphasizing the design criteria on-demand release response to stimuli. sheds light on important factors governing controlled of anti-cancer drugs from PEG hydrogels, considering various commercial viability these critical l...

Since the first 70 years of reporting cancer chemotherapy, malignant tumors have been second most common cause death in children and adults. Currently, commonly used anti-cancer methods include surgery, radiotherapy, immunotherapy. Although these treatment could alleviate cancer, they lead to different forms side effects no particularly significant effect on prolonging patients’ life span. Glyc...

Anti-cancer drug delivery based on nanocages is important step in development process due to reducing side effects and drug-releasing near the tumor cell. We have studied interaction of bendamustine anti-cancer with Al/B-N/P utilization density functional theory (DFT) approach both gas water phases at B3LYP/6-31G (d,p) level theory. Results show that quantum parameters were somewhat varied by a...

curcumin is a natural polyphenolic compound with anti-cancer, anti-inflammatory, and anti-oxidation properties. low water solubility and rapid hydrolytic degradation are two challenges limiting use of curcumin as therapeutic agent. in the current study, the role of the bovine serum albumin (bsa), β-lactoglobulin and casein, as food-grade biopolymers and safe drug delivery systems, on the physic...