conclusions the results of this study show that patients with sle have poorer hrqol in physical components whereas the mental component of qol is relatively similar to healthy individuals. depression and anxiety were not related to clinical manifestations of sle. however, the sf domain of hrqol was the most susceptible component of qol, which was affected by sle clinical variables. the high est...

BACKGROUND Herba Rhodiolae is a traditional Chinese medicine used by the Tibetan people for treating hypoxia related diseases such as anxiety. Based on the previous work, we developed and patented an anti-anxiety herbal formula Fu Fang Jin Jing Oral Liquid (FJJOL) with Herba Rhodiolae as a chief ingredient. In this study, the anti-hypoxia and anti-anxiety effects of FJJOL in a high altitude for...

The present study was undertaken to evaluate Tagara and Jatamansi for certain CNS activities to ascertain the basis for their use as a sedative and hypnotics. The drugs were evaluated for hypnotic and sedative, anti anxiety, anti depressant and anti psychotic activities using standard experimental protocol. The data generated suggests that the test drugs Tagara and Jatamansi have complex CNS ac...

BACKGROUND The placebo effect in relieving negative emotion arousal is poorly understood. AIMS We examined whether placebo expectation established with noise stimuli could have a transferable anxiolytic effect on negative emotion arousal. METHODS In Experiment 1, noise intensity was surreptitiously lowered during placebo condition in the preconditioning phase to reinforce placebo expectatio...

The design and synthesis of the novel 2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,7-a]indole 5 is described. This azepinoindole has excellent affinity for 5-HT(2C) (K(i) 4.8 nM) and modest selectivity over 5-HT(2A) ( approximately 4-fold). Several N- and C(11)-substituted analogues of 5 were prepared, as were a number of biaryl indoline derivatives. The anxiolytic potential for the azepinoindole tem...

neurogenesis occurs throughout life in several regions of the brain. in this lecture, a new sight for the role of the dentate gyrus and adult hippocampal neurogenesis in anxiety disorders will be discussed. the region that has obtained the most attention for its involvement in the neurogenesis of affective and anxiety disorders are the hippocampal and dentate gyrus. evidence strongly suggests t...

Phlegmatic people dislike taking benzodiazepine drugs. In those with low'anxiety traits benzodiazepines are dysphoric and may paradoxically increase anxiety.' In normal subjects benzodiazepines improve performance under experimental stress but worsen it under conditions of low stress.2 Benzodiazepines relieve preoperative anxiety in patients with high anticipatory anxiety but not in those with ...

Powerful behavioural treatments for many patients with anxiety disorders have been widely available since the 1970s. Despite this, the majority of such patients have continued to be treated with psychotrophic drugs. Recent litigation against the manufacturers of benzodiazepine drugs has made the public increasingly concerned about the prescription of anxiolytic agents. In parallel with the fall...

It was shown that the anxiolytic effect of Selank is comparable to that of classical benzodiazepine drugs and that the basis of their mechanism of action may be similar. These data suggest that the presence of Selank may change the action of classical benzodiazepine drugs. To test this hypothesis, we evaluated the anxiolytic activity of Selank and diazepam in rats both under conditions of unpre...