= Abstract =Percentages and ratios of peripheral blood T lymphocytes and T cell subsets were sequentially measured by monoclonal antibodies in 15 psoriatic patients treated with anthralin-UV radiation. Time sequence was divided into 1) pre 2) between 1 and 24 hours post 3) 4 or 5 days post 4) 8 days post 5) 11 or 12 days post treatment. There was no significant difference between the results ob...

Topical therapy as monotherapy is useful in psoriasis patients with mild disease. Topical agents are also used as adjuvant for moderate-to-severe disease who are being concurrently treated with either ultraviolet light or systemic medications. Emollients are useful adjuncts to the treatment of psoriasis. Use of older topical agents such as anthralin and coal tar has declined over the years. How...

Inhibition of 5-lipoxygenase by anthralin (1) and 41 derivatives is determined: the acids 38 and 39, the lactones 40-42 and 9-anthrone (8) are the most potent inhibitors, the lactone 41 reaching the efficacy of nordihydroguaiaretic acid (NDGA). The results were correlated with the hydrophilic/lipophilic balance of the test compounds and their clinical efficacy as far as known. There is no corre...

Sir, Nail psoriasis affects 20–55% of psoriatic patients. It often represents a significant cause of distress because of the visible lesions and the chronic course of the disease. Treatment options include corticosteroids, vitamin D3 analogues, 5-fluorouracil, urea, anthralin, cyclosporine and radiotherapy (1). Tazarotene is an acetylenic retinoid with documented therapeutic results in skin pso...

Alopecia areata is a non-scarring hair loss disorder that can occur in any part of the body, ranging from a small patch to complete loss of hair, without significant age or sex predisposition. Although the exact etiology is unknown, several patient-specific genetic, immunological, and environmental factors have been implicated. The underlying pathology is probably peribulbar infiltration of CD4...

The syntheses, the biological evaluation, and the structure-activity relationships of a novel series of 1,8-dihydroxy-9(10H)-anthracenones bearing acyl-, alkyl-, or alkylidene-linked aromatic substituents in the 10-position are described. The phenylacyl and phenylalkylidene analogs were far more potent inhibitors of 5-lipoxygenase (5-LO) from bovine polymorphonuclear leukocytes (IC50 values in ...

The encapsulation behaviour and the resulting transition metal ion sensing capabilities of a 5-arm star-shaped polymer bearing terpyridine ligands on its periphery are described.