With the technological advances in cancer diagnosis and treatment, the survival rates for patients with cancer are prolonged. The issue of figuring out how to improve the life quality of patients with cancer has become increasingly prominent. Pain, especially bone pain, is the most common symptom in malignancy patients, which seriously affects the life quality of patients with cancer. The resea...

Visceral pain describes pain emanating from the thoracic, pelvic, or abdominal organs. In contrast to somatic pain, visceral pain is generally vague, poorly localized, and characterized by hypersensitivity to a stimulus such as organ distension. Animal models have played a pivotal role in our understanding of the mechanisms underlying the pathophysiology of visceral pain. This review focuses on...

There exists currently a fair degree of introspection in the pain research community about the value of animal research. This review represents a defense of animal research in pain. We discuss the inherent advantage of animal models over human research as well as the crucial complementary roles animal studies play vis-à-vis human imaging and genetic studies. Finally, we discuss recent developme...

Background and Objectives: Little is known about the association between dietary protein intake and clinical manifestations in osteoarthritis (OA) patients. We aimed to determine the correlation between dietary protein intake and pain severity, functional status, and body composition indices in patients with knee OA. Materials and Methods: This cross-sectional study was performed on 220 OA pat...

Fibromyalgia patients are suffering distressing pain-centered symptoms, and therefore the clarification of fibromyalgia pathophysiology and the development of more effective therapeutic options are urgent issues. In the preclinical phase of analgesic drug development, experimental animal pain models have been widely used to investigate analgesic efficacies of candidate agents. In this approach,...

OBJECTIVE To describe the currently used animal models for the study of osteoarthritis (OA) pain, with an emphasis on small animals (predominantly mice and rats). OUTLINE Narrative review summarizing the opportunities and limitations of the most commonly used small animal models for the study of pain and pain pathways associated with OA, and discussing currently used methods for pain assessme...

introduction: pain research using animal models is related to ethical concerns, so invertebrates and insects have been recommended by researchers. in the present study, the nociceptive and antinociceptive effects of capsaicin, aspirin, morphine and chili extract were examined using fruit fly (drosophila melanogaster) as an alternative for rodent pain model. methods: stage 3 of larvae and adult ...

systematic review of the evidence for central nervous system plasticity in animal models of inflammatory-mediated gastrointestinal pain". Running Title: CNS plasticity in animal models of visceral pain Abstract Background: Abdominal pain frequently accompanies inflammatory disorders of the

We agree with Bara and Joffe that there is a need for improvement of reporting quality in animal research (AR) [1]. Presenting details on both methods used and potential cofounders during AR is not only important to reproduce results, and to ensure animal welfare (AW) and public support, it is a duty when animals are compromised, stressed or sacrificed to understand diseases or to identify trea...