نتایج جستجو برای: angptl8 protein
تعداد نتایج: 1234778 فیلتر نتایج به سال:
هدف: پروتئین شبه آنژیوپروتئین 8 یک عامل گردشی منتج از هپاتوسیتها است که سطوح تریگلیسریدهای پلاسما را تنظیم میکند. هدف از تحقیق حاضر بررسی پاسخ سطوح پلاسمایی پروتئین شبه آنژیوپوئیتین 8 (ANGPTL8) به فعالیت ورزشی حاد در مردان جوان فعال میباشد. روش‌شناسی: یازده مرد جوان سالم و فعال (سن 63/3±00/24 سال، شاخص توده بدنی 00/2±98/22 کیلوگرم بر متر مربع) در این مطالعه شرکت نمودند. فعالیت ورزشی حاد شا...
Objective(s): Hepatocellular carcinoma (HCC) is one of the leading fatal neoplasms and the most common primary liver malignancy worldwide. Peptide hormone ANGPTL8 (betatrophin) may act as an important regulator in HCC development through the Wnt/β-catenin pathway. We aimed to evaluate the effects of recombinant ANGPTL8 on Wnt/β-catenin signaling in human liver carcinom...
Background & Objective: Angiopoietin-like Proteins 8 (ANGPTL8) which secreted form adipose tissue due to downstream PGC-1α pathways, is the main factor for regeneration of beta cell. The aim of this study was to investigate the effect of 4 endurance training program on PGC-1α expression in adipose tissue, ANGPTL8 serum concentration and beta cell function (HOMA.B) in diabetic rats. Materials & ...
Regenerative therapy in diabetes with the capacity to reconstitute a functional β-cell mass sufficient for glycemic control holds the promise to effectively prevent the development of devastating late complications due to the unique ability of the β-cell to sense and regulate blood-glucose levels. An ability that cannot be mimicked by insulin replacement therapy or any other means of current tr...
O n the steamy fi rst day of August 1966, Charles Whitman took an elevator to the top fl oor of the University of Texas Tower in Austin. The 25-year-old climbed the stairs to the observation deck, lugging with him a footlocker full of guns and ammunition. At the top, he killed a receptionist with the butt of his rifl e. Two families of tourists came up the stairwell; he shot at them at point-bl...
Background and Aims : Angiopoietin-like protein 3 (ANGPTL3) inhibition reduces LDL-cholesterol (LDL-C), triglycerides (TG) HDL-C in patients with hyperlipidemia. Post-prandially, ANGPTL8 forms a complex ANGPTL3; the ANGPTL3/8 inhibits lipoprotein lipase 100-fold more potently circulates at much lower levels than ANGPTL3 alone. This phase 1 study assessed safety pharmacology of single ascending ...
(Cell 153, 747–758; May 9, 2013) In this article, we claimed that Angptl-8, which we termed betatrophin and is also referred to in the literature as TD26, RIFL, C19orf80, and Lipasin, was the agent by which the insulin antagonist S961 induces robust b cell replication in mice. Gusarova et al., in aMatters Arising article, subsequently showed that targeted Angptl-8/betatrophin overexpression in ...
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